Pyrrolidinone and Piperidinone Isocyanides from Isocyano Esters

Naïm Ait Sidhoum (1) , Aurélie dos Santos (1) , Laurent El Kaim (1) , Laetitia Legras (1)

1 DCSO - Laboratoire de synthèse organique

The alkylation of isocyano esters with 1,2- and 1,3-dibromoalkanes affords bromo isocyanides. Under treatment with various amines the latter form new isocyano-substituted lactams, which can be further used in Passerini or Ugi reactions.

Domaines: Chimie organique

Naïm Ait Sidhoum, Aurélie dos Santos, Laurent El Kaim, Laetitia Legras. Pyrrolidinone and Piperidinone Isocyanides from Isocyano Esters. European Journal of Organic Chemistry, 2014, 2014 (23), pp.4949-4952. ⟨10.1002/ejoc.201402572⟩. ⟨hal-01065722⟩