Reductive Passerini/Tsuji-Trost Strategy towards beta,gamma-Unsaturated Amides
Résumé
The Passerini reaction of α,β-unsaturated aldehydes with formic acid followed by a reductive Tsuji-Trost reaction affords β,γ-unsaturated amides. The overall process may be viewed as a one-carbon homologation of unsaturated aldehydes into amides.