A convergent route to functional protected amines, diamines, and β-amino acids

Abstract : Phthalimide protected amines react with NBS under peroxide initiation to give geminal phthalimido-bromo derivatives, which are readily converted into the corresponding xanthates. These xanthates in turn undergo radical additions to numerous olefins, providing a convergent and modular access to densely functionalized protected amines and diamines.
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https://hal-polytechnique.archives-ouvertes.fr/hal-01082412
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Submitted on : Thursday, November 13, 2014 - 2:32:11 PM
Last modification on : Thursday, February 7, 2019 - 5:03:28 PM

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Songzhe Han, Rachel A. Jones, Béatrice Quiclet-Sire, Samir Z. Zard. A convergent route to functional protected amines, diamines, and β-amino acids. Tetrahedron, Elsevier, 2014, 70 (40), pp.7192-7206. ⟨10.1016/j.tet.2014.07.055⟩. ⟨hal-01082412⟩

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