Numerical simulations of maternal blood flows in the human placenta: estimation of the wall shear stress exerted on the syncytiotrophoblast

Edouard Lecarpentier (1) , Mrugank Bhatt (2) , Thierry Fournier (1) , Abdul Barakat (2) , Vassilis Tsatsaris (3, 1)

1 IMAGINE - U1163 - Imagine - Institut des maladies génétiques
2 LadHyX - Laboratoire d'hydrodynamique
3 Hôpital Cochin [AP-HP]

The primary culture of syncytiotrophoblast (ST) is a model of the human placental endocrinian functions. In vivo the ST is submitted to the fluid shear stress generated by maternal blood flows. Our hypothesis is that the shear stress could modulate the secretory functions of the ST. The aim of this study is to determine the gradients of wall shear stress exerted in vivo by the maternal blood flows on the ST.

Domains: Fluid mechanics [physics.class-ph]; Development Biology

Edouard Lecarpentier, Mrugank Bhatt, Thierry Fournier, Abdul Barakat, Vassilis Tsatsaris. Numerical simulations of maternal blood flows in the human placenta: estimation of the wall shear stress exerted on the syncytiotrophoblast. Placenta, 2014, 35 (9), pp.A105. ⟨10.1016/j.placenta.2014.06.343⟩. ⟨hal-01117126⟩