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Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2015

Structure of a left-handed DNA G-quadruplex

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Abstract

Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.

Dates and versions

hal-01140567 , version 1 (08-04-2015)

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Wan Jun Chung, Heddi Brahim, Emmanuelle Schmitt, Kah Wai Lim, Yves Mechulam, et al.. Structure of a left-handed DNA G-quadruplex. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (9), pp.2729-2733. ⟨10.1073/pnas.1418718112⟩. ⟨hal-01140567⟩
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