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Structure of a left-handed DNA G-quadruplex
Abstract : Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.
https://hal-polytechnique.archives-ouvertes.fr/hal-01140567
Contributor : Denis Roura <>
Submitted on : Wednesday, April 8, 2015 - 10:50:34 PM
Last modification on : Wednesday, July 29, 2020 - 4:10:05 PM
Contributor : Denis Roura <>
Submitted on : Wednesday, April 8, 2015 - 10:50:34 PM
Last modification on : Wednesday, July 29, 2020 - 4:10:05 PM
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