Structure of a left-handed DNA G-quadruplex

Wan Jun Chung 1 Heddi Brahim 1 Emmanuelle Schmitt 2 Kah Wai Lim 1 Yves Mechulam 2 Anh Tuân Phan 1
1 School of Physical and Mathematical Sciences
2 BIOC - Laboratoire de Biochimie de l'Ecole polytechnique
Abstract : Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.
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Submitted on : Wednesday, April 8, 2015 - 10:50:34 PM
Last modification on : Wednesday, March 27, 2019 - 3:56:02 PM

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Wan Jun Chung, Heddi Brahim, Emmanuelle Schmitt, Kah Wai Lim, Yves Mechulam, et al.. Structure of a left-handed DNA G-quadruplex. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2015, 112 (9), pp.2729-2733. ⟨10.1073/pnas.1418718112 ⟩. ⟨hal-01140567⟩

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