Structure of a left-handed DNA G-quadruplex

Wan Jun Chung 1 Heddi Brahim 1 Emmanuelle Schmitt 2 Kah Wai Lim 1 Yves Mechulam 2 Anh Tuân Phan 1
1 School of Physical and Mathematical Sciences
2 BIOC - Laboratoire de Biochimie de l'Ecole polytechnique
Abstract : Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.
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Article dans une revue
Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2015, 112 (9), pp.2729-2733. 〈10.1073/pnas.1418718112 〉
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https://hal-polytechnique.archives-ouvertes.fr/hal-01140567
Contributeur : Denis Roura <>
Soumis le : mercredi 8 avril 2015 - 22:50:34
Dernière modification le : jeudi 7 février 2019 - 14:29:35

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Wan Jun Chung, Heddi Brahim, Emmanuelle Schmitt, Kah Wai Lim, Yves Mechulam, et al.. Structure of a left-handed DNA G-quadruplex. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2015, 112 (9), pp.2729-2733. 〈10.1073/pnas.1418718112 〉. 〈hal-01140567〉

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