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A variable reference trajectory for model-free glycemia regulation

Abstract : The control design of an artificial pancreas, a hot research topic in diabetology, is tackled via the newly introduced model-free control and its corresponding "intelligent" proportional controller, which were already quite successful in many concrete and diverse situations. It results in an insulin injection for type 1 diabetes which displays via constant references a good nocturnal/fasting response, but unfortunately a poor postprandial behavior due to long hyperglycemia. When a variable reference is introduced, that switches between a constant one, when glycemia is more or less normal or moderate, and an exponential decay reference path, when a high glycemia rate indicates a meal intake, the results in silico, which employ real clinical data, become excellent. We obtain a bolus-shaped insulin injection rate during postprandial phases. The hyperglycemic peaks are therefore lowered a lot.
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Submitted on : Wednesday, April 15, 2015 - 11:02:33 AM
Last modification on : Tuesday, November 22, 2022 - 2:26:16 PM
Long-term archiving on: : Tuesday, April 18, 2017 - 4:37:31 PM


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  • HAL Id : hal-01141268, version 1


Taghreed Mohammad Ridha, Claude Moog, Emmanuel Delaleau, Michel Fliess, Cédric Join. A variable reference trajectory for model-free glycemia regulation. SIAM Conference on Control & its Applications, SIAM CT15, Jul 2015, Paris, France. pp.60-67. ⟨hal-01141268⟩



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