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Journal articles
Radical-based route to 2-(trifluoromethyl)-1,3,4-oxadiazoles and trifluoromethyl-substituted polycyclic 1,2,4-triazoles and dihydrofurans.
Abstract : O-Ethyl S-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]methyl xanthate was readily prepared on a large scale and shown to undergo very efficient intermolecular radical additions to unactivated alkenes. The products were further elaborated by exploiting both radical and ionic processes to provide a variety of trifluoromethyl-substituted derivatives, including medicinally relevant triazoles. In particular, the application of a radical allylation on the initial adducts leads to structures that are able to undergo intramolecular [4 + 2] cycloaddition reactions.
https://hal-polytechnique.archives-ouvertes.fr/hal-01152227
Contributor : Denis Roura Connect in order to contact the contributor
Submitted on : Friday, May 15, 2015 - 3:45:23 PM
Last modification on : Thursday, March 5, 2020 - 6:30:57 PM
Contributor : Denis Roura Connect in order to contact the contributor
Submitted on : Friday, May 15, 2015 - 3:45:23 PM
Last modification on : Thursday, March 5, 2020 - 6:30:57 PM