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Journal articles

Dynamics of receptor-mediated nanoparticle internalization into endothelial cells.

Abstract : Nanoparticles offer a promising medical tool for targeted drug delivery, for example to treat inflamed endothelial cells during the development of atherosclerosis. To inform the design of such therapeutic strategies, we develop a computational model of nanoparticle internalization into endothelial cells, where internalization is driven by receptor-ligand binding and limited by the deformation of the cell membrane and cytoplasm. We specifically consider the case of nanoparticles targeted against ICAM-1 receptors, of relevance for treating atherosclerosis. The model computes the kinetics of the internalization process, the dynamics of binding, and the distribution of stresses exerted between the nanoparticle and the cell membrane. The model predicts the existence of an optimal nanoparticle size for fastest internalization, consistent with experimental observations, as well as the role of bond characteristics, local cell mechanical properties, and external forces in the nanoparticle internalization process.
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Contributor : Denis Roura Connect in order to contact the contributor
Submitted on : Tuesday, July 21, 2015 - 11:02:08 AM
Last modification on : Thursday, March 5, 2020 - 6:31:01 PM
Long-term archiving on: : Thursday, October 22, 2015 - 10:34:26 AM


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David Gonzalez-Rodriguez, Abdul I Barakat. Dynamics of receptor-mediated nanoparticle internalization into endothelial cells.. PLoS ONE, Public Library of Science, 2014, 10 (4), pp.e0122097. ⟨10.1371/journal.pone.0122097⟩. ⟨hal-01178880⟩



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