L. Räber, L. Wohlwend, M. Wigger, M. Togni, S. Wandel et al., Five-Year Clinical and Angiographic Outcomes of a Randomized Comparison of Sirolimus-Eluting and Paclitaxel-Eluting Stents: Results of the Sirolimus-Eluting Versus Paclitaxel-Eluting Stents for Coronary Revascularization LATE Trial, Circulation, vol.123, issue.24, pp.2819-2828, 2011.
DOI : 10.1161/CIRCULATIONAHA.110.004762

G. Buchanan, S. Basavarajaiah, and A. Chieffo, Stent Thrombosis: Incidence, Predictors and New Technologies, Thrombosis, vol.7, issue.7, pp.1-12, 2012.
DOI : 10.1016/j.jacc.2011.05.050

URL : http://doi.org/10.1155/2012/956962

K. Birkmeier, A. Kastrati, R. Byrne, H. Holle, S. Schulz et al., Five-year clinical outcomes of sirolimus-eluting versus paclitaxel-eluting stents in high-risk patients, Catheterization and Cardiovascular Interventions, vol.119, issue.4, pp.494-501, 2011.
DOI : 10.1002/ccd.22757

S. Sakai, K. Mizuno, S. Yokoyama, J. Tanabe, T. Shinada et al., Morphologic changes in infarct-related plaque after coronary stent placement: a serial angioscopy study, ACC Current Journal Review, vol.13, issue.3, pp.1558-1565, 2003.
DOI : 10.1016/j.accreview.2004.02.052

Y. Ueda, S. Nanto, K. Komamura, and K. Kodama, Neointimal coverage of stents in human coronary arteries observed by angioscopy, Journal of the American College of Cardiology, vol.23, issue.2, pp.341-346, 1994.
DOI : 10.1016/0735-1097(94)90417-0

T. Lüscher, J. Steffel, F. Eberli, M. Joner, G. Nakazawa et al., Drug-Eluting Stent and Coronary Thrombosis: Biological Mechanisms and Clinical Implications, Circulation, vol.115, issue.8, p.17325255, 2007.
DOI : 10.1161/CIRCULATIONAHA.106.675934

J. Liuzzo, J. Ambrose, and J. Coppola, Sirolimus-and taxol-eluting stents differ towards intimal hyperplasia and re-endothelialization, The Journal of Invasive Cardiology, vol.17, pp.497-502, 2005.

A. Finn, G. Nakazawa, M. Joner, F. Kolodgie, E. Mont et al., Vascular Responses to Drug Eluting Stents: Importance of Delayed Healing, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.27, issue.7, pp.1500-1510, 2007.
DOI : 10.1161/ATVBAHA.107.144220

H. Li, Z. Lj, C. Bh, X. Zhou, K. Su et al., Inhibitory Effect of Paclitaxel on Endothelial Cell Adhesion and Migration, Pharmacology, vol.85, issue.3, pp.136-145, 2010.
DOI : 10.1159/000280587

J. Daemen, P. Wenaweser, K. Tsuchida, L. Abrecht, S. Vaina et al., Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study, The Lancet, vol.369, issue.9562, pp.667-678, 2007.
DOI : 10.1016/S0140-6736(07)60314-6

F. Bozsak, J. Chomaz, and A. Barakat, Modeling the transport of drugs eluted from stents: physical phenomena driving drug distribution in the arterial wall, Biomechanics and Modeling in Mechanobiology, vol.4, issue.2, pp.327-347, 2014.
DOI : 10.1007/s10237-013-0546-4

URL : https://hal.archives-ouvertes.fr/hal-01048584

M. Atherton and R. Bates, Robust optimization of cardiovascular stents: a comparison of methods, Engineering Optimization, vol.1993, issue.2, pp.207-217, 1080.
DOI : 10.1214/ss/1177012413

K. Srinivas, T. Nakayama, M. Ohta, S. Obayashi, and T. Yamaguchi, Studies on Design Optimization of Coronary Stents, Journal of Medical Devices, vol.2, issue.1, 2008.
DOI : 10.1115/1.2885145

T. Gundert, A. Marsden, W. Yang, and J. Ladisa, Optimization of Cardiovascular Stent Design Using Computational Fluid Dynamics, Journal of Biomechanical Engineering, vol.134, issue.1, p.22482657, 2012.
DOI : 10.1115/1.4005542

T. Gundert, A. Marsden, Y. W. Marks, D. Ladisa, and J. , Identification of Hemodynamically Optimal Coronary Stent Designs Based on Vessel Caliber, IEEE Transactions on Biomedical Engineering, vol.59, issue.7, p.22547450, 1992.
DOI : 10.1109/TBME.2012.2196275

W. Wu, L. Petrini, D. Gastaldi, T. Villa, M. Vedani et al., Finite Element Shape Optimization for Biodegradable Magnesium Alloy Stents, Annals of Biomedical Engineering, vol.30, issue.9, pp.2829-2840, 2010.
DOI : 10.1007/s10439-010-0057-8

L. Timmins, M. Moreno, C. Meyer, J. Criscione, A. Rachev et al., Stented artery biomechanics and device design optimization, Medical & Biological Engineering & Computing, vol.27, issue.3, pp.505-513, 2007.
DOI : 10.1007/s11517-007-0180-3

S. Pant, G. Limbert, N. Curzen, and N. Bressloff, Multiobjective design optimisation of coronary stents, Biomaterials, vol.32, issue.31, pp.7755-7773, 2011.
DOI : 10.1016/j.biomaterials.2011.07.059

S. Pant, N. Bressloff, and G. Limbert, Geometry parameterization and multidisciplinary constrained optimization of coronary stents, Biomechanics and Modeling in Mechanobiology, vol.198, issue.45???46, pp.61-82, 2012.
DOI : 10.1007/s10237-011-0293-3

D. Jones, A taxonomy of global optimization methods based on response surfaces, Journal of Global Optimization, vol.21, issue.4, pp.345-383, 2001.
DOI : 10.1023/A:1012771025575

J. Grogan, S. Leen, and P. Mchugh, Optimizing the design of a bioabsorbable metal stent using computer simulation methods, Biomaterials, vol.34, issue.33, pp.8049-8060, 2013.
DOI : 10.1016/j.biomaterials.2013.07.010

J. Aragon, S. Kar, F. Tio, B. Trauthen, A. Parisky et al., The effect of variable release kinetics on paclitaxel efficacy from a drug eluting stent in a porcine model, EuroIntervention, vol.1, pp.228-235, 2005.

L. Lao and S. Venkatraman, Adjustable paclitaxel release kinetics and its efficacy to inhibit smooth muscle cells proliferation, Journal of Controlled Release, vol.130, issue.1, pp.9-14, 2008.
DOI : 10.1016/j.jconrel.2008.05.008

D. Frey, M. Billinger, P. Meier, O. Beslac, R. Grossenbacher et al., Endothelialization of sirolimus-eluting stents with slow and extended drug release in the porcine overstretch model, The Journal of Invasive Cardiology, vol.20, pp.631-634, 2008.

C. Pan, J. Tang, Y. Weng, J. Wang, and N. Huang, Preparation and in vitro release profiles of drug-eluting controlled biodegradable polymer coating stents, Colloids and Surfaces B: Biointerfaces, vol.73, issue.2, pp.199-206, 2009.
DOI : 10.1016/j.colsurfb.2009.05.016

G. Guagliumi, H. Ikejima, V. Sirbu, H. Bezerra, G. Musumeci et al., Impact of Drug Release Kinetics on Vascular Response to Different Zotarolimus-Eluting Stents Implanted in Patients With Long Coronary Stenoses, JACC: Cardiovascular Interventions, vol.4, issue.7, pp.778-785, 2011.
DOI : 10.1016/j.jcin.2011.04.007

B. Balakrishnan, J. Dooley, G. Kopia, and E. Edelman, Intravascular drug release kinetics dictate arterial drug deposition, retention, and distribution, Journal of Controlled Release, vol.123, issue.2, pp.100-108, 2007.
DOI : 10.1016/j.jconrel.2007.06.025

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702153

A. Tzafriri, A. Groothuis, G. Price, and E. Edelman, Stent elution rate determines drug deposition and receptor-mediated effects, Journal of Controlled Release, vol.161, issue.3, pp.918-926, 2012.
DOI : 10.1016/j.jconrel.2012.05.039

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616625

S. Venkatraman and F. Boey, Release profiles in drug-eluting stents: Issues and uncertainties, Journal of Controlled Release, vol.120, issue.3, pp.149-160, 2007.
DOI : 10.1016/j.jconrel.2007.04.022

B. Tesfamariam, Drug Release Kinetics From Stent Device-Based Delivery Systems, Journal of Cardiovascular Pharmacology, vol.51, issue.2, pp.118-125, 2008.
DOI : 10.1097/FJC.0b013e318158540f

P. Belitz, Applications on Multi-Dimensional Sphere Packings: Derivative-Free Optimization, 2011.

P. Belitz and T. Bewley, New horizons in sphere-packing theory, part II: lattice-based derivative-free optimization via global surrogates, Journal of Global Optimization, vol.199, issue.39, pp.1-31, 2012.
DOI : 10.1007/s10898-012-9866-7

A. Tzafriri, A. Levin, and E. Edelman, Diffusion-limited binding explains binary dose response for local arterial and tumour drug delivery, Cell Proliferation, vol.22, issue.3, pp.348-363, 2009.
DOI : 10.1111/j.1365-2184.2009.00602.x

S. Garg and P. Serruys, Coronary Stents, Journal of the American College of Cardiology, vol.56, issue.10, pp.1-42, 2010.
DOI : 10.1016/j.jacc.2010.06.007

P. Libby, Inflammation in atherosclerosis, Nature, vol.103, issue.6917, pp.868-874, 2002.
DOI : 10.1074/jbc.274.45.32048

Z. Huang and J. Tarbell, Numerical simulation of mass transfer in porous media of blood vessel walls, Advanced Drug Delivery Reviews, vol.273, pp.464-477, 1997.

A. Hindmarsh and P. Brown, SUNDIALS, ACM Transactions on Mathematical Software, vol.31, issue.3, 2005.
DOI : 10.1145/1089014.1089020

C. Vergara and P. Zunino, Multiscale Boundary Conditions for Drug Release from Cardiovascular Stents, Multiscale Modeling & Simulation, vol.7, issue.2, pp.565-588, 2008.
DOI : 10.1137/07070214X

J. Siepmann and N. Peppas, Higuchi equation: Derivation, applications, use and misuse, International Journal of Pharmaceutics, vol.418, issue.1, pp.6-12, 2011.
DOI : 10.1016/j.ijpharm.2011.03.051

G. Guagliumi, V. Sirbu, G. Musumeci, R. Gerber, G. Biondi-zoccai et al., Examination of the In Vivo Mechanisms of Late Drug-Eluting Stent Thrombosis, JACC: Cardiovascular Interventions, vol.5, issue.1, pp.12-20, 2012.
DOI : 10.1016/j.jcin.2011.09.018

A. Finn, M. Joner, G. Nakazawa, F. Kolodgie, J. Newell et al., Pathological Correlates of Late Drug-Eluting Stent Thrombosis: Strut Coverage as a Marker of Endothelialization, Circulation, vol.115, issue.18, pp.2435-2441, 2007.
DOI : 10.1161/CIRCULATIONAHA.107.693739

K. Kamath, J. Barry, and K. Miller, The Taxus??? drug-eluting stent: A new paradigm in controlled drug delivery, Advanced Drug Delivery Reviews, vol.58, issue.3, pp.412-436, 2006.
DOI : 10.1016/j.addr.2006.01.023

S. Mcginty, S. Mckee, R. Wadsworth, and C. Mccormick, Modelling drug-eluting stents, Mathematical Medicine and Biology, vol.28, issue.1, p.20413417, 2011.
DOI : 10.1093/imammb/dqq003

Y. Toiyama, Y. Inoue, J. Hiro, E. Ojima, H. Watanabe et al., The range of optimal concentration and mechanisms of paclitaxel in radio-enhancement in gastrointestinal cancer cell lines, Cancer Chemotherapy and Pharmacology, vol.57, issue.6, pp.733-742, 2006.
DOI : 10.1007/s00280-006-0327-1

D. Axel, W. Kunert, C. Goggelmann, M. Oberhoff, C. Herdeg et al., Paclitaxel Inhibits Arterial Smooth Muscle Cell Proliferation and Migration In Vitro and In Vivo Using Local Drug Delivery, Circulation, vol.96, issue.2, pp.636-645, 1997.
DOI : 10.1161/01.CIR.96.2.636

M. Poon, S. Marx, R. Gallo, J. Badimon, M. Taubman et al., Rapamycin inhibits vascular smooth muscle cell migration., Journal of Clinical Investigation, vol.98, issue.10, pp.2277-2283, 1996.
DOI : 10.1172/JCI119038

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC507677

C. Matter, I. Rozenberg, A. Jaschko, H. Greutert, D. Kurz et al., Effects of Tacrolimus or Sirolimus on Proliferation of Vascular Smooth Muscle and Endothelial Cells, Journal of Cardiovascular Pharmacology, vol.48, issue.6, pp.286-292, 2006.
DOI : 10.1097/01.fjc.0000248233.22570.8b

J. Sun, S. Marx, H. Chen, M. Poon, A. Marks et al., Role for p27Kip1 in Vascular Smooth Muscle Cell Migration, Circulation, vol.103, issue.24, pp.2967-2972, 2001.
DOI : 10.1161/01.CIR.103.24.2967

K. Inoue, Pathological Perspective of Drug-Eluting Stent Thrombosis, Thrombosis, vol.5, issue.1, pp.1-8, 2012.
DOI : 10.1016/S1054-8807(03)00132-7

R. Wessely, B. Blaich, R. Belaiba, S. Merl, A. Görlach et al., Comparative characterization of cellular and molecular anti-restenotic profiles of paclitaxel and sirolimus. Implications for local drug delivery, Thrombosis and Haemostasis, vol.97, pp.1003-1012, 2007.
DOI : 10.1160/TH06-10-0586

R. Ee and C. Rogers, Pathobiologic responses to stenting, The American Journal of Cardiology, vol.81, issue.98, pp.4-6, 1998.

B. Klugherz, G. Llanos, W. Lieuallen, G. Kopia, G. Papandreou et al., Twenty-eight-day efficacy and phamacokinetics of the sirolimus-eluting stent, Coronary Artery Disease, vol.13, issue.3, pp.183-188, 2002.
DOI : 10.1097/00019501-200205000-00008

S. Marx, H. Totary-jain, and A. Marks, Vascular Smooth Muscle Cell Proliferation in Restenosis, Circulation: Cardiovascular Interventions, vol.4, issue.1, pp.104-111, 2011.
DOI : 10.1161/CIRCINTERVENTIONS.110.957332

G. Acharya and K. Park, Mechanisms of controlled drug release from drug-eluting stents, Advanced Drug Delivery Reviews, vol.58, issue.3, pp.387-401, 2006.
DOI : 10.1016/j.addr.2006.01.016

A. Booker, J. Dennis, P. Frank, D. Serafini, V. Torczon et al., A rigorous framework for optimization of expensive functions by surrogates, Structural Optimization, vol.16, issue.1, pp.1-13, 1999.
DOI : 10.1007/BF01197708

D. Krige, A statistical approach to some basic mine valuation problems on the witwatersrand, Journal of the Chemical, Metallurgical and Mining Society of South Africa, vol.52, pp.119-139, 1951.

G. Matheron, Principles of geostatistics, Economic Geology, vol.58, issue.8, pp.1246-1266, 1963.
DOI : 10.2113/gsecongeo.58.8.1246

A. Forrester, A. Sóbester, and A. Keane, Engineering design via surrogate modelling a practical guide, 2008.

A. Marsden, M. Wang, J. Dennis, and P. Moin, Optimal Aeroacoustic Shape Design Using the Surrogate Management Framework, Optimization and Engineering, vol.5, issue.2, pp.235-262, 2004.
DOI : 10.1023/B:OPTE.0000033376.89159.65

A. Marsden, M. Wang, J. Dennis, and P. Moin, Trailing-edge noise reduction using derivative-free optimization and large-eddy simulation, Journal of Fluid Mechanics, vol.572, pp.13-23, 2007.
DOI : 10.1017/S0022112006003235

A. Marsden, J. Feinstein, and C. Taylor, A computational framework for derivative-free optimization of cardiovascular geometries, Computer Methods in Applied Mechanics and Engineering, vol.197, issue.21-24, pp.1890-1905, 2008.
DOI : 10.1016/j.cma.2007.12.009

W. Yang, J. Feinstein, and A. Marsden, Constrained optimization of an idealized Y-shaped baffle for the Fontan surgery at rest and exercise, Computer Methods in Applied Mechanics and Engineering, vol.199, issue.33-36, pp.2135-2149, 2010.
DOI : 10.1016/j.cma.2010.03.012

R. Sibson, A brief description of natural neighbor interpolation Wiley series in probability and mathematical statistics, Interpreting multivariate data, pp.21-36, 1981.

B. Radeleff, R. Lopez-benitez, U. Stampfl, S. Stampfl, C. Sommer et al., Paclitaxel-induced Arterial Wall Toxicity and Inflammation: Tissue Uptake in Various Dose Densities in a Minipig Model, Journal of Vascular and Interventional Radiology, vol.21, issue.8, pp.1262-1270, 2010.
DOI : 10.1016/j.jvir.2010.02.020

L. Lei, S. Guo, W. Chen, H. Rong, and F. Lu, Stents as a platform for drug delivery, Expert Opinion on Drug Delivery, vol.104, issue.6, p.21548713, 2011.
DOI : 10.1016/j.jcin.2008.07.003

A. Ielasi, A. Latib, and A. Colombo, Current and future drug-eluting coronary stent technology, Expert Review of Cardiovascular Therapy, vol.9, issue.4, pp.485-503, 2011.
DOI : 10.1586/erc.11.5

H. Van-beusekom, F. Saia, J. Zindler, P. Lemos, S. Swager-ten-hoor et al., Drug-eluting stents show delayed healing: paclitaxel more pronounced than sirolimus, European Heart Journal, vol.28, issue.8, pp.974-979, 2007.
DOI : 10.1093/eurheartj/ehm064

S. Farhan, R. Hemetsberger, J. Matiasek, C. Strehblow, N. Pavo et al., Implantation of paclitaxel-eluting stent impairs the vascular compliance of arteries in porcine coronary stenting model, Atherosclerosis, vol.202, issue.1, pp.144-151, 2009.
DOI : 10.1016/j.atherosclerosis.2008.04.039

A. Farb, P. Heller, S. Shroff, L. Cheng, F. Kolodgie et al., Pathological Analysis of Local Delivery of Paclitaxel Via a Polymer-Coated Stent, Circulation, vol.104, issue.4, pp.473-479, 2001.
DOI : 10.1161/hc3001.092037

M. Davies, P. Richardson, N. Woolf, D. Katz, and J. Mann, Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content., Heart, vol.69, issue.5, pp.377-381, 1993.
DOI : 10.1136/hrt.69.5.377

A. Lopez-candales, D. Holmes, S. Liao, M. Scott, S. Wickline et al., Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms, The American Journal of Pathology, vol.150, pp.993-1007, 1997.

W. Gray and J. Granada, Drug-Coated Balloons for the Prevention of Vascular Restenosis, Circulation, vol.121, issue.24, pp.2672-2680, 2010.
DOI : 10.1161/CIRCULATIONAHA.110.936922

U. Kaul and A. Mansoor, Choice of drug-eluting stent???evidence-based or empirical, Journal of Indian College of Cardiology, vol.2, issue.1, pp.22-28, 2012.
DOI : 10.1016/S1561-8811(12)80005-8

S. Li, Y. Wang, L. Gai, T. Yang, H. Liu et al., Evaluation of neointimal coverage and apposition with various drug-eluting stents over 12months after implantation by optical coherence tomography, International Journal of Cardiology, vol.162, issue.3, pp.166-171, 2013.
DOI : 10.1016/j.ijcard.2011.05.076

S. Garg and P. Serruys, Coronary Stents, Journal of the American College of Cardiology, vol.56, issue.10, pp.43-78, 2010.
DOI : 10.1016/j.jacc.2010.06.008

S. Garg, M. Magro, and P. Serruys, 627?drug-eluting stents, Comprehensive Biomaterials, vol.6, pp.427-448, 2011.

A. Abizaid, Sirolimus-eluting coronary stents: a review, Vascular Health and Risk Management, vol.3, issue.2, pp.191-201, 2007.
DOI : 10.2147/vhrm.2007.3.2.191

P. Smits, E. Kedhi, K. Royaards, K. Joesoef, J. Wassing et al., 2-Year Follow-Up of a Randomized Controlled Trial of Everolimus- and Paclitaxel-Eluting Stents for Coronary Revascularization in Daily Practice, Journal of the American College of Cardiology, vol.58, issue.1, pp.11-18, 2011.
DOI : 10.1016/j.jacc.2011.02.023

G. Stone, A. Rizvi, K. Sudhir, W. Newman, R. Applegate et al., Randomized Comparison of Everolimus- and Paclitaxel-Eluting Stents, Journal of the American College of Cardiology, vol.58, issue.1, pp.19-25, 2011.
DOI : 10.1016/j.jacc.2011.02.022

F. Alfonso and M. Pérez-vizcayno, Drug-eluting balloons for restenosis after stent implantation, The Lancet, vol.381, issue.9865, pp.431-433, 2013.
DOI : 10.1016/S0140-6736(12)62120-5

B. Cortese, G. Sgueglia, and J. Granada, Paclitaxel coated balloons, the time for awareness has come, International Journal of Cardiology, vol.164, issue.1, p.22658568, 2013.
DOI : 10.1016/j.ijcard.2012.05.037

B. Scheller, C. Hehrlein, W. Bocksch, W. Rutsch, D. Haghi et al., Treatment of Coronary In-Stent Restenosis with a Paclitaxel-Coated Balloon Catheter, New England Journal of Medicine, vol.355, issue.20, pp.2113-2124, 2006.
DOI : 10.1056/NEJMoa061254