A Convergent Radical Based Route to Trifluoromethyl Ketones and to α,β-Unsaturated Trifluoromethyl Ketones

Abstract : A convergent synthesis of trifluoromethyl ketones and alpha beta-unsaturated trifluoromethyl ketones is described, starting with aliphatic iodides and dithiocarbonates (xanthates) and exploiting both the alpha- and beta-fragmentations of a sulfonyl radical. The transformation initially furnishes the ketones in a masked enol carbonate form, from which they can be easily regenerated.
Type de document :
Article dans une revue
Organic Letters, American Chemical Society, 2015, 17 (12), pp.3058-3061. 〈10.1021/acs.orglett.5b01344〉
Liste complète des métadonnées

https://hal-polytechnique.archives-ouvertes.fr/hal-01186604
Contributeur : Denis Roura <>
Soumis le : mardi 25 août 2015 - 12:41:16
Dernière modification le : jeudi 10 mai 2018 - 02:07:45

Identifiants

Citation

Lucile Anthore, Samir Z. Zard. A Convergent Radical Based Route to Trifluoromethyl Ketones and to α,β-Unsaturated Trifluoromethyl Ketones. Organic Letters, American Chemical Society, 2015, 17 (12), pp.3058-3061. 〈10.1021/acs.orglett.5b01344〉. 〈hal-01186604〉

Partager

Métriques

Consultations de la notice

116