A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes

Pierre Salomon (1) , Wioletta Kosnik (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activated magnesium metal. (C) 2014 Elsevier Ltd. All rights reserved.

Domaines: Chimie organique

Pierre Salomon, Wioletta Kosnik, Samir Z. Zard. A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes. Tetrahedron, 2015, 71 (39), pp.7144-7153. ⟨10.1016/j.tet.2014.11.021⟩. ⟨hal-01224738⟩