A convergent, modular access to α-chloro-trifluoromethyl derivatives and to 1,1-difluoroalkenes
Abstract
An efficient protocol for the preparation of S-(1-chloro-2,2,2-trifluoroethyl)-O-ethyl xanthate is reported. This reagent serves as a versatile precursor of highly functionalized gem-difluoroalkenes through various inter- and intramolecular radical reactions and subsequent reduction with activated magnesium metal. (C) 2014 Elsevier Ltd. All rights reserved.
Domains
Organic chemistry
Origin : Files produced by the author(s)
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