ROS Detection and Quantification with Lanthanide-Based Nanosensors

Mouna Abdesselem 1 Thierry Gacoin 2 Jean-Pierre Boilot 2 Pierre-Louis Tharaux 3 Antigoni Alexandrou 1 Cedric Bouzigues 1
1 LOB - Laboratoire d'optique et biosciences
2 LPMC - Laboratoire de physique de la matière condensée
3 PARCC - U970 - Paris-Centre de Recherche Cardiovasculaire
Abstract : Reactive oxygen species (ROS), in particular hydrogen peroxide (H2O2), are produced as secondary cellular messengers involved in a variety of signaling pathways. Detecting ROS concentration in cells and in living organisms is particularly important because ROS oxidative stress plays a complex role in multiple pathologies: inflammatory processes, neurodegenerative diseases, and cancer. We first report on an europium-based H2O2 sensor (Y0.6Eu0.4VO4) that shows red, oxidant-dependant, reversible luminescence modulation used in cells in culture.
Type de document :
Poster
59th Annual Meeting of the Biophysical-Society, Feb 2015, Baltimore, United States. Biophysical Journal, 108 (2), pp.483a, 2015, 〈10.1016/j.bpj.2014.11.2640〉
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Soumis le : jeudi 3 décembre 2015 - 13:57:32
Dernière modification le : jeudi 10 mai 2018 - 02:08:01

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Mouna Abdesselem, Thierry Gacoin, Jean-Pierre Boilot, Pierre-Louis Tharaux, Antigoni Alexandrou, et al.. ROS Detection and Quantification with Lanthanide-Based Nanosensors. 59th Annual Meeting of the Biophysical-Society, Feb 2015, Baltimore, United States. Biophysical Journal, 108 (2), pp.483a, 2015, 〈10.1016/j.bpj.2014.11.2640〉. 〈hal-01237532〉

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