Computational Fluid Dynamic Simulations of Maternal Circulation: Wall Shear Stress in the Human Placenta and Its Biological Implications

E. Lecarpentier; M. Bhatt; G. Bertin; B. Deloison; L. Salomon; P. Deloron; T. Fournier; Abdul I Barakat; V. Tsatsaris

Computational Fluid Dynamic Simulations of Maternal Circulation: Wall Shear Stress in the Human Placenta and Its Biological Implications

E. Lecarpentier ^{1, 2, 3, 4, *} M. Bhatt ⁵ G. Bertin ⁶ B. Deloison ^{7, 6, 8} L. Salomon ^{9, 3, 7} P. Deloron ⁶ T. Fournier ^{1, 2, 3, 4} Abdul I Barakat ⁵ V. Tsatsaris ^{4, 1, 2, 3}

* Corresponding author

1 U1139 - Physiopathologie et Pharmacotoxicologie Placentaire Humaine

2 PremUp Foundation

3 Service de Gynécologie et Obstétrique [Cochin]

4 DHU Risques Et Grossesse

5 LadHyX - Laboratoire d'hydrodynamique

6 MERIT - UMR_D 216 - Mère et enfant face aux infections tropicales

7 FETUS - EA 7328 - Fédération pour la recherche en explorations et thérapeutiques innovantes in utéro

8 CHU Necker - Enfants Malades [AP-HP]

9 PARCC - UMR-S U970 - Paris-Centre de Recherche Cardiovasculaire

Abstract : In the human placenta the maternal blood circulates in the intervillous space (IVS). The syncytiotrophoblast (STB) is in direct contact with maternal blood. The wall shear stress (WSS) exerted by the maternal blood flow on the STB has not been evaluated. Our objective was to determine the physiological WSS exerted on the surface of the STB during the third trimester of pregnancy.

Document type :

Journal articles

Domain :

Physics [physics] / Mechanics [physics] / Mechanics of the fluids [physics.class-ph]

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Computational Fluid Dynamic Simulations of Maternal Circulation: Wall Shear Stress in the Human Placenta and Its Biological Implications

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