A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

Shi-Guang Li; Fernando Portela-Cubillo; Samir Z. Zard

doi:10.1021/acs.orglett.6b00656

A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

Shi-Guang Li ¹ Fernando Portela-Cubillo ¹ Samir Z. Zard ¹

1 DCSO - Laboratoire de synthèse organique

Abstract : A radical based synthesis of a broad variety of protected enantiopure alpha-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-a-amino acids ideally equipped for native chemical ligation.

Type de document :

Article dans une revue

Organic Letters, American Chemical Society, 2016, 18 (8), pp.1888-1891. 〈10.1021/acs.orglett.6b00656〉

Domaine :

Chimie / Chimie organique

Liste complète des métadonnées

https://hal-polytechnique.archives-ouvertes.fr/hal-01323304
Contributeur : Denis Roura <>
Soumis le : lundi 30 mai 2016 - 13:08:40
Dernière modification le : jeudi 10 mai 2018 - 02:07:41

A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

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A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

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