A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

Shi-Guang Li (1) , Fernando Portela-Cubillo (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

A radical based synthesis of a broad variety of protected enantiopure alpha-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-a-amino acids ideally equipped for native chemical ligation.

Domains: Organic chemistry

Shi-Guang Li, Fernando Portela-Cubillo, Samir Z. Zard. A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids. Organic Letters, 2016, 18 (8), pp.1888-1891. ⟨10.1021/acs.orglett.6b00656⟩. ⟨hal-01323304⟩