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A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids

Shi-Guang Li 1 Fernando Portela-Cubillo 1 Samir Z. Zard 1
1 DCSO - Laboratoire de synthèse organique
Abstract : A radical based synthesis of a broad variety of protected enantiopure alpha-amino acids, including fluorinated derivatives, is described. The radical addition furnishes naturally latent mercapto-a-amino acids ideally equipped for native chemical ligation.
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https://hal-polytechnique.archives-ouvertes.fr/hal-01323304
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Submitted on : Monday, May 30, 2016 - 1:08:40 PM
Last modification on : Thursday, March 5, 2020 - 6:33:30 PM

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Shi-Guang Li, Fernando Portela-Cubillo, Samir Z. Zard. A Convergent Synthesis of Enantiopure Open-Chain, Cyclic, and Fluorinated α-Amino Acids. Organic Letters, American Chemical Society, 2016, 18 (8), pp.1888-1891. ⟨10.1021/acs.orglett.6b00656⟩. ⟨hal-01323304⟩

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