 |
École polytechnique Open archive |  |
 |
Conference papers
Elastocapillary Instability in Mitochondrial Fission
Abstract : Mitochondria are dynamic cell organelles that constantly undergo fission and fusion events. These dynamical processes, which tightly regulate mitochondrial morphology, are essential for cell physiology. We propose an elastocapillary mechanical instability as a mechanism for mitochondrial fission [Gonzalez-Rodriguez et al., Phys. Rev. Lett. 115, 088102 (2015)]. We experimentally induce mitochondrial fission by rupturing the cell's plasma membrane. We present a stability analysis that successfully explains the observed fission wavelength and the role of mitochondrial morphology in the occurrence of fission events. Our results show that the laws of fluid mechanics can describe mitochondrial morphology and dynamics. © 2016 Biophysical Society. Published by Elsevier Inc. All rights reserved.
https://hal-polytechnique.archives-ouvertes.fr/hal-01324881
Contributor : Denis Roura <>
Submitted on : Wednesday, June 1, 2016 - 3:42:34 PM
Last modification on : Friday, April 10, 2020 - 5:27:52 PM
Contributor : Denis Roura <>
Submitted on : Wednesday, June 1, 2016 - 3:42:34 PM
Last modification on : Friday, April 10, 2020 - 5:27:52 PM
Links full text
