A Radical Bidirectional Fragment Coupling Route to Unsymmetrical Ketones

Abstract : A powerful strategy for the regioselective bidirectional synthesis of unsymmetrically substituted ketones is described, relying on the fact that the exchange of a xanthate is much faster than the radical addition to an unactivated alkene. The use of an alkene as the formal "alkylating" agent associated with the tolerance for numerous functional groups and the mildness of the experimental conditions removes many of the problems associated with the classical ionic and transition-metal-based approaches.
Type de document :
Article dans une revue
Journal of the American Chemical Society, American Chemical Society, 2016, 138 (27), pp.8404-8407. 〈10.1021/jacs.6b05344 〉
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https://hal-polytechnique.archives-ouvertes.fr/hal-01445472
Contributeur : Denis Roura <>
Soumis le : mardi 24 janvier 2017 - 21:25:41
Dernière modification le : jeudi 10 mai 2018 - 02:07:35

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Lucile Anthore-Dalion, Qiang Liu, Samir Z. Zard. A Radical Bidirectional Fragment Coupling Route to Unsymmetrical Ketones. Journal of the American Chemical Society, American Chemical Society, 2016, 138 (27), pp.8404-8407. 〈10.1021/jacs.6b05344 〉. 〈hal-01445472〉

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