Selective Tsuji-Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles - École polytechnique Access content directly
Journal Articles Chemical Communications Year : 2016

Selective Tsuji-Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles

Abstract

The 4,5-dihydropyrazole motif has drawn considerable attention over the years as it was shown to exhibit a plethora of biological and pharmacological properties, including anticancer, antibacterial, antifungal, antiviral, and anti-inflammatory properties. As such, it has been the target of a number of methods and drug discovery programs. We report here a straightforward and highly selective approach featuring a key palladium-catalysed Tsuji-Trost type C-allylation and subsequent intramolecular 1,4-addition of hydrazones.

Dates and versions

hal-01623194 , version 1 (25-10-2017)

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Cite

Elhachemia Elmamouni, M. Cattoen, Marie Cordier, Janine Cossy, Stellios Arseniyadis, et al.. Selective Tsuji-Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles. Chemical Communications, 2016, 52 (100), pp.14490-14493 ⟨10.1039/c6cc08171a⟩. ⟨hal-01623194⟩
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