Selective Tsuji-Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles

Abstract : The 4,5-dihydropyrazole motif has drawn considerable attention over the years as it was shown to exhibit a plethora of biological and pharmacological properties, including anticancer, antibacterial, antifungal, antiviral, and anti-inflammatory properties. As such, it has been the target of a number of methods and drug discovery programs. We report here a straightforward and highly selective approach featuring a key palladium-catalysed Tsuji-Trost type C-allylation and subsequent intramolecular 1,4-addition of hydrazones.
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Chemical Communications, Royal Society of Chemistry, 2016, 52 (100), pp.14490-14493 〈10.1039/c6cc08171a〉
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https://hal-polytechnique.archives-ouvertes.fr/hal-01623194
Contributeur : Denis Roura <>
Soumis le : mercredi 25 octobre 2017 - 10:35:34
Dernière modification le : samedi 14 avril 2018 - 00:12:02

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Elhachemia Elmamouni, M. Cattoen, Marie Cordier, Janine Cossy, Stellios Arseniyadis, et al.. Selective Tsuji-Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles. Chemical Communications, Royal Society of Chemistry, 2016, 52 (100), pp.14490-14493 〈10.1039/c6cc08171a〉. 〈hal-01623194〉

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