Dynamic compensation and homeostasis: a feedback control perspective

Abstract : "Dynamic compensation" is a robustness property where a perturbed biological circuit maintains a suitable output [Karin O., Swisa A., Glaser B., Dor Y., Alon U. (2016). Mol. Syst. Biol., 12: 886]. In spite of several attempts, no fully convincing analysis seems now to be on hand. This communication suggests an explanation via "model-free control" and the corresponding "intelligent" controllers [Fliess M., Join C. (2013). Int. J. Contr., 86, 2228-2252], which are already successfully applied in many concrete situations. As a byproduct this setting provides also a slightly different presentation of homeostasis, or "exact adaptation," where the working conditions are assumed to be "mild." Several convincing, but academic, computer simulations are provided and discussed.
Complete list of metadatas

Cited literature [10 references]  Display  Hide  Download

https://hal-polytechnique.archives-ouvertes.fr/hal-01684422
Contributor : Michel Fliess <>
Submitted on : Monday, January 15, 2018 - 3:13:02 PM
Last modification on : Wednesday, March 27, 2019 - 4:41:28 PM
Long-term archiving on : Wednesday, May 23, 2018 - 8:59:15 PM

File

DynamCompens18.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : hal-01684422, version 2
  • ARXIV : 1801.04959

Citation

Michel Fliess, Cédric Join. Dynamic compensation and homeostasis: a feedback control perspective. [Research Report] Ecole polytechnique X. 2018, pp.1-22. ⟨hal-01684422v2⟩

Share

Metrics

Record views

780

Files downloads

330