m6A mRNA Destiny: Chained to the rhYTHm by the YTH-Containing Proteins

Abstract : The control of gene expression is a multi-layered process occurring at the level of DNA, RNA, and proteins. With the emergence of highly sensitive techniques, new aspects of RNA regulation have been uncovered leading to the emerging field of epitranscriptomics dealing with RNA modifications. Among those post-transcriptional modifications, N6-methyladenosine (m 6 A) is the most prevalent in messenger RNAs (mRNAs). This mark can either prevent or stimulate the formation of RNA-protein complexes, thereby influencing mRNA-related mechanisms and cellular processes. This review focuses on proteins containing a YTH domain (for YT521-B Homology), a small building block, that selectively detects the m 6 A nucleotide embedded within a consensus motif. Thereby, it contributes to the recruitment of various effectors involved in the control of mRNA fates through adjacent regions present in the different YTH-containing proteins.
Complete list of metadatas

Cited literature [81 references]  Display  Hide  Download

https://hal-polytechnique.archives-ouvertes.fr/hal-01996108
Contributor : Aurélien Arnoux <>
Submitted on : Monday, January 28, 2019 - 10:48:15 AM
Last modification on : Wednesday, March 27, 2019 - 3:56:02 PM
Long-term archiving on : Monday, April 29, 2019 - 2:47:16 PM

File

genes-10-00049-v2.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Ditipriya Hazra, Clément Chapat, Marc Graille. m6A mRNA Destiny: Chained to the rhYTHm by the YTH-Containing Proteins. Genes, MDPI, 2019, 10 (1), pp.49. ⟨https://www.mdpi.com/2073-4425/10/1/49⟩. ⟨10.3390/genes10010049⟩. ⟨hal-01996108⟩

Share

Metrics

Record views

54

Files downloads

68