m6A mRNA Destiny: Chained to the rhYTHm by the YTH-Containing Proteins

Ditipriya Hazra (1) , Clément Chapat (1) , Marc Graille (1)

1 BIOC - Laboratoire de Biochimie de l'Ecole polytechnique

The control of gene expression is a multi-layered process occurring at the level of DNA, RNA, and proteins. With the emergence of highly sensitive techniques, new aspects of RNA regulation have been uncovered leading to the emerging field of epitranscriptomics dealing with RNA modifications. Among those post-transcriptional modifications, N6-methyladenosine (m 6 A) is the most prevalent in messenger RNAs (mRNAs). This mark can either prevent or stimulate the formation of RNA-protein complexes, thereby influencing mRNA-related mechanisms and cellular processes. This review focuses on proteins containing a YTH domain (for YT521-B Homology), a small building block, that selectively detects the m 6 A nucleotide embedded within a consensus motif. Thereby, it contributes to the recruitment of various effectors involved in the control of mRNA fates through adjacent regions present in the different YTH-containing proteins.

Mots clés: epitranscriptomics; mRNA methylation; m6A readers; YTH domain

Domaines: Biologie moléculaire; Biologie cellulaire; Bio-Informatique, Biologie Systémique [q-bio.QM]; Cancer

Ditipriya Hazra, Clément Chapat, Marc Graille. m6A mRNA Destiny: Chained to the rhYTHm by the YTH-Containing Proteins. Genes, 2019, 10 (1), pp.49. ⟨10.3390/genes10010049⟩. ⟨hal-01996108⟩