Gold-Catalyzed Formal Dehydro-Diels-Alder Reactions of Ene-Ynamide Derivatives Bearing Terminal Alkyne Chains - École polytechnique Accéder directement au contenu
Article Dans Une Revue Angewandte Chemie International Edition Année : 2018

Gold-Catalyzed Formal Dehydro-Diels-Alder Reactions of Ene-Ynamide Derivatives Bearing Terminal Alkyne Chains

Résumé

A new protocol for the synthesis of a variety of N-containing aromatic heterocycles by a formal gold-catalyzed dehydro-Diels-Alder reaction of ynamide derivatives has been developed. Deuterium-labeling experiments and kinetic studies support the involvement of a dual gold catalysis mechanism in which a gold acetylide moiety adds onto an aurated keteneiminium.

Domaines

Chimie organique
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Dates et versions

hal-02090677 , version 1 (05-04-2019)

Identifiants

Citer

Qing Zhao, David Fabian León rayo, Dominic Campeau, Martin Daenen, Fabien Gagosz. Gold-Catalyzed Formal Dehydro-Diels-Alder Reactions of Ene-Ynamide Derivatives Bearing Terminal Alkyne Chains: Scope and Mechanistic Studies. Angewandte Chemie International Edition, 2018, 57 (41), pp.13603-13607. ⟨10.1002/anie.201807136⟩. ⟨hal-02090677⟩
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