Abstract : An intramolecular aryne Diels-Alder reaction with a furan moiety was applied to the synthesis of dihydrobenzo[ de]isochromenes as intermediates toward naphthalimides. After oxidation, this method offers an efficient approach for the synthesis of substituted naphthalimides, which showed potent cytotoxic activity against HT-29 human cancer cell line.
https://hal-polytechnique.archives-ouvertes.fr/hal-02091716
Contributor : Aurélien Arnoux
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Submitted on : Saturday, April 6, 2019 - 11:15:17 AM
Last modification on : Friday, April 12, 2019 - 1:31:50 AM
