Intramolecular Aryne-Furan Cycloadditions for the Synthesis of Anticancer Naphthalimides

Abstract : An intramolecular aryne Diels-Alder reaction with a furan moiety was applied to the synthesis of dihydrobenzo[ de]isochromenes as intermediates toward naphthalimides. After oxidation, this method offers an efficient approach for the synthesis of substituted naphthalimides, which showed potent cytotoxic activity against HT-29 human cancer cell line.
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Submitted on : Saturday, April 6, 2019 - 11:15:17 AM
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Sébastien Prevost, Ambre Dezaire, Alexandre Escargueil. Intramolecular Aryne-Furan Cycloadditions for the Synthesis of Anticancer Naphthalimides. Journal of Organic Chemistry, American Chemical Society, 2018, 83 (8), pp.4871-4881. ⟨10.1021/acs.joc.8b00531⟩. ⟨hal-02091716⟩

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