Palladium-catalysed O -Allylation of α-Hydroxyphosphonates: An Expedient Entry into Phosphono-oxaheterocycles

Mansour Dolé Kerim; Martin Cattoen; Nicolas Fincias; Aurélie Dos santos; Stellios Arseniyadis; Laurent El Kaim

Palladium-catalysed O -Allylation of α-Hydroxyphosphonates: An Expedient Entry into Phosphono-oxaheterocycles

Mansour Dolé Kerim ¹ Martin Cattoen ² Nicolas Fincias ^{1, 2} Aurélie Dos santos ¹ Stellios Arseniyadis ^{2, *} Laurent El Kaim ^{1, *}

* Corresponding author

1 DCSO - Laboratoire de synthèse organique

2 School of Biological and Chemical Sciences, Queen Mary University of London

Abstract : We report here an unprecedented palladium‐catalysed O‐allylation of α‐hydroxyphosphonates. The method was eventually included in a sequential Pudovik/Tsuji‐Trost type O‐allylation/Ring‐Closing Metathesis to afford a variety of phosphorylated heterocycles of various sizes ranging from 5 to 16 starting from readily available aldehydes.

Keywords : α-Hydroxyphosphonates O-allylation Palladium Pudovik reaction Ring-closing metathesis Metacyclophanes

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

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https://hal-polytechnique.archives-ouvertes.fr/hal-02091718
Contributor : Aurélien Arnoux <>
Submitted on : Saturday, April 6, 2019 - 11:35:22 AM
Last modification on : Tuesday, July 16, 2019 - 4:10:09 PM

Palladium-catalysed O -Allylation of α-Hydroxyphosphonates: An Expedient Entry into Phosphono-oxaheterocycles

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Palladium-catalysed O -Allylation of α-Hydroxyphosphonates: An Expedient Entry into Phosphono-oxaheterocycles

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