Chemoselective Reduction: Xanthates as Traceless Precursors of Polyfunctionalized α,α-Dichloroketones

Lucile Anthore-Dalion (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

The use of BEt3·H2O has allowed the chemoselective reductive dexanthylation in the presence of the very fragile α,α-dichloroketone motif. This has solved a major hurdle in our approach to this important, but hitherto grossly understudied, family of compounds and opened access to a number of very useful synthetic transformations.

Domains: Chemical Sciences; Organic chemistry

Lucile Anthore-Dalion, Samir Z. Zard. Chemoselective Reduction: Xanthates as Traceless Precursors of Polyfunctionalized α,α-Dichloroketones. Organic Letters, 2017, 19 (20), pp.5545-5548. ⟨10.1021/acs.orglett.7b02636⟩. ⟨hal-02091721⟩