Chemoselective Reduction: Xanthates as Traceless Precursors of Polyfunctionalized α,α-Dichloroketones

Abstract : The use of BEt3·H2O has allowed the chemoselective reductive dexanthylation in the presence of the very fragile α,α-dichloroketone motif. This has solved a major hurdle in our approach to this important, but hitherto grossly understudied, family of compounds and opened access to a number of very useful synthetic transformations.
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Submitted on : Saturday, April 6, 2019 - 11:50:15 AM
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Lucile Anthore-Dalion, Samir Zard. Chemoselective Reduction: Xanthates as Traceless Precursors of Polyfunctionalized α,α-Dichloroketones. Organic Letters, American Chemical Society, 2017, 19 (20), pp.5545-5548. ⟨https://pubs.acs.org/doi/10.1021/acs.orglett.7b02636⟩. ⟨10.1021/acs.orglett.7b02636⟩. ⟨hal-02091721⟩

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