Xanthate-mediated intermolecular alkylation of pyrazines

Qi Huang; Qi Qin; Samir Zard

doi:10.1016/j.tet.2018.08.040

Journal articles

Xanthate-mediated intermolecular alkylation of pyrazines

Qi Huang ^{1, *} Qi Qin ¹ Samir Zard ^{1, *}

* Corresponding author

1 DCSO - Laboratoire de synthèse organique

Abstract : An expedient approach for the intermolecular C-H functionalization of pyrazines and other heteroarenes by the radical chemistry of xanthates is reported. Incorporation of a multitude of functional alkyl groups onto these heteroarenes proceeds in good yield and good to excellent regioselectivity, leading to highly functionalized heteroaromatics.

Keywords : Pyrazines C-H functionalization of heteroaromatics Xanthates Minisci reaction

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

Complete list of metadata

https://hal-polytechnique.archives-ouvertes.fr/hal-02094257
Contributor : Aurélien Arnoux Connect in order to contact the contributor
Submitted on : Tuesday, April 9, 2019 - 3:21:32 PM
Last modification on : Tuesday, January 4, 2022 - 4:01:02 AM

Xanthate-mediated intermolecular alkylation of pyrazines

Licence

Identifiers

Collections

Citation

Export

Metrics

Xanthate-mediated intermolecular alkylation of pyrazines

Licence

Identifiers

Collections

Citation

Export

Share

Metrics