Xanthate-mediated intermolecular alkylation of pyrazines

Qi Huang 1, * Qi Qin 1 Samir Zard 1, *
Abstract : An expedient approach for the intermolecular C-H functionalization of pyrazines and other heteroarenes by the radical chemistry of xanthates is reported. Incorporation of a multitude of functional alkyl groups onto these heteroarenes proceeds in good yield and good to excellent regioselectivity, leading to highly functionalized heteroaromatics.
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Submitted on : Tuesday, April 9, 2019 - 3:21:32 PM
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Qi Huang, Qi Qin, Samir Zard. Xanthate-mediated intermolecular alkylation of pyrazines. Tetrahedron, Elsevier, 2018, 74 (40), pp.5804-5817. ⟨https://www.sciencedirect.com/science/article/pii/S0040402018310068⟩. ⟨10.1016/j.tet.2018.08.040⟩. ⟨hal-02094257⟩

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