Xanthate-mediated intermolecular alkylation of pyrazines

Qi Huang; Qi Qin; Samir Zard

doi:10.1016/j.tet.2018.08.040

Journal articles

Xanthate-mediated intermolecular alkylation of pyrazines

Qi Huang ^{1, *} Qi Qin ¹ Samir Zard ^{1, *}

* Corresponding author

1 DCSO - Laboratoire de synthèse organique

Abstract : An expedient approach for the intermolecular C-H functionalization of pyrazines and other heteroarenes by the radical chemistry of xanthates is reported. Incorporation of a multitude of functional alkyl groups onto these heteroarenes proceeds in good yield and good to excellent regioselectivity, leading to highly functionalized heteroaromatics.

Keywords : Pyrazines C-H functionalization of heteroaromatics Xanthates Minisci reaction

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

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https://hal-polytechnique.archives-ouvertes.fr/hal-02094257
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Submitted on : Tuesday, April 9, 2019 - 3:21:32 PM
Last modification on : Friday, April 12, 2019 - 1:31:51 AM

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