TiCl4-Mediated Synthesis of 3,4-Hetero-Disubstituted Isocoumarins by Means of Isocyanide Insertion Reactions

Abstract : The isocyanide insertion into sulfanyl-phthalides under Lewis acid conditions is reported with full details. This sequential three-component reaction affords a new straightforward and highly convenient method for the preparation of 3-amino-4-sulfanyl isocoumarins, the potential of which is still unexplored.
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https://hal-polytechnique.archives-ouvertes.fr/hal-02095068
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Submitted on : Wednesday, April 10, 2019 - 11:05:03 AM
Last modification on : Wednesday, July 3, 2019 - 10:48:05 AM

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Sudipta Ponra, Aude Nyadanu, Sylvie Maurin, Laurent El Kaim, Laurence Grimaud, et al.. TiCl4-Mediated Synthesis of 3,4-Hetero-Disubstituted Isocoumarins by Means of Isocyanide Insertion Reactions. SYNTHESIS, Georg Thieme Verlag, 2018, 50 (06), pp.1331-1342. ⟨10.1055/s-0036-1591733⟩. ⟨hal-02095068⟩

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