Convergent Routes to Pyrroles Exploiting the Unusual Radical Chemistry of Xanthates – An Overview

Béatrice Quiclet-Sire (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

Convergent routes to a variety of pyrroles involving radical additions of xanthates are described. Emphasis is placed on reactions leading to the formation of 1,4-diketones or 1,4-ketoaldehydes or their synthetic equivalents, which can then be condensed with ammonia or primary amines in a variation of the classical Paal–Knorr synthesis of pyrroles. The modification of pyrroles by direct radical addition is also discussed.

Keywords: pyrroles; Paal–Knorr reaction; 1; 4-diketones; radical addition; xanthates

Domains: Chemical Sciences; Organic chemistry

Béatrice Quiclet-Sire, Samir Z. Zard. Convergent Routes to Pyrroles Exploiting the Unusual Radical Chemistry of Xanthates – An Overview. SYNLETT, 2017, 28 (20), pp.2685-2696. ⟨10.1055/s-0036-1590809⟩. ⟨hal-02095091⟩