, the Agence Nationale pour la Recherche
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Crystal Structure of the Eukaryotic Ribosome, Science, vol.330, issue.6008, pp.1203-1209, 2010. ,
Uncovering the assembly pathway of human ribosomes and its emerging links to disease, EMBO J, vol.38, p.100278, 2019. ,
Eukaryotic ribosome assembly, Annu. Rev. Biochem, vol.88, 2018. ,
Ribosome assembly coming into focus, Nat. Rev. Mol. Cell Biol, vol.20, pp.116-131, 2019. ,
Rare ribosomopathies: insights into mechanisms of cancer, Nat. Rev. Cancer, vol.19, pp.228-238, 2019. ,
Ribosome biogenesis in cancer: new players and therapeutic avenues, Nat. Rev. Cancer, vol.18, pp.51-63, 2018. ,
Noncoding RNAs in eukaryotic ribosome biogenesis and function, Nature Structural & Molecular Biology, vol.22, issue.1, pp.11-19, 2015. ,
Evidence for rRNA 2?-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes, Proceedings of the National Academy of Sciences, vol.114, issue.49, pp.12934-12939, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-02191312
Identification of sites of 2?-O-methylation vulnerability in human ribosomal RNAs by systematic mapping, Scientific Reports, vol.7, issue.1, p.11490, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01799319
Landscape of the complete RNA chemical modifications in the human 80S ribosome, Nucleic Acids Research, vol.46, issue.18, pp.9289-9298, 2018. ,
Visualization of chemical modifications in the human 80S ribosome structure, Nature, vol.551, issue.7681, pp.472-477, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-02409680
The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA, Wiley Interdisciplinary Reviews: RNA, vol.3, issue.3, pp.397-414, 2011. ,
?View From A Bridge?: A New Perspective on Eukaryotic rRNA Base Modification, Trends in Biochemical Sciences, vol.40, issue.10, pp.560-575, 2015. ,
Translating the Genome in Time and Space: Specialized Ribosomes, RNA Regulons, and RNA-Binding Proteins, Annual Review of Cell and Developmental Biology, vol.31, issue.1, pp.31-54, 2015. ,
Heterogeneity and specialized functions of translation machinery: from genes to organisms, Nature Reviews Genetics, vol.19, issue.7, pp.431-452, 2018. ,
Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function, RNA Biology, vol.14, issue.9, pp.1138-1152, 2016. ,
Identification of the locations of the methyl groups in 18 S ribosomal RNA from Xenopus laevis and man, Journal of Molecular Biology, vol.189, issue.4, pp.681-699, 1986. ,
Locations of methyl groups in 28 S rRNA of Xenopus laevis and man, Journal of Molecular Biology, vol.201, issue.2, pp.289-314, 1988. ,
N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation, Nature Chemical Biology, vol.15, issue.1, pp.88-94, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02409786
DNA targeting specificity of RNA-guided Cas9 nucleases, Nature Biotechnology, vol.31, issue.9, pp.827-832, 2013. ,
Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1, Nucleic Acids Research, vol.43, issue.4, pp.2242-2258, 2015. ,
Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants, Journal of Applied Crystallography, vol.26, issue.6, pp.795-800, 1993. ,
How good are my data and what is the resolution?, Acta Crystallographica Section D Biological Crystallography, vol.69, issue.7, pp.1204-1214, 2013. ,
Phasercrystallographic software, Journal of Applied Crystallography, vol.40, issue.4, pp.658-674, 2007. ,
The Phyre2 web portal for protein modeling, prediction and analysis, Nature Protocols, vol.10, issue.6, pp.845-858, 2015. ,
Structural and functional studies of Bud23?Trm112 reveal 18S rRNAN7-G1575 methylation occurs on late 40S precursor ribosomes, Proceedings of the National Academy of Sciences, vol.111, issue.51, pp.E5518-E5526, 2014. ,
Features and development ofCoot, Acta Crystallographica Section D Biological Crystallography, vol.66, issue.4, pp.486-501, 2010. ,
, , 2016.
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome, Nature Methods, vol.12, issue.8, pp.767-772, 2015. ,
Studies on the Methylation of Cytoplasmic Ribosomal RNA from Cultured Higher Plant Cells, European Journal of Biochemistry, vol.98, issue.1, pp.203-214, 1979. ,
UniProt: the universal protein knowledgebase, Nucleic Acids Research, vol.45, issue.D1, pp.D158-D169, 2016. ,
New and continuing developments at PROSITE, Nucleic Acids Research, vol.41, issue.D1, pp.D344-D347, 2012. ,
The Glutamine Residue of the Conserved GGQ Motif inSaccharomyces cerevisiaeRelease Factor eRF1 Is Methylated by the Product of theYDR140wGene, Journal of Biological Chemistry, vol.280, issue.4, pp.2439-2445, 2004. ,
HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1, FEBS Letters, vol.582, issue.16, pp.2352-2356, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00348794
Mechanism of activation of methyltransferases involved in translation by the Trm112 ?hub? protein, Nucleic Acids Research, vol.39, issue.14, pp.6249-6259, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00624935
Molecular Basis for Bacterial Class I Release Factor Methylation by PrmC, Molecular Cell, vol.20, issue.6, pp.917-927, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00090289
Phylogenomic analysis of 16S rRNA:(guanine?N2) methyltransferases suggests new family members and reveals highly conserved motifs and a domain structure similar to other nucleic acid amino?methyltransferases, The FASEB Journal, vol.14, issue.14, pp.2365-2368, 2000. ,
The Yeast Translation Release Factors Mrf1p and Sup45p (eRF1) Are Methylated, Respectively, by the Methyltransferases Mtq1p and Mtq2p, Journal of Biological Chemistry, vol.281, issue.5, pp.2562-2571, 2005. ,
A subcellular map of the human proteome, Science, vol.356, issue.6340, p.eaal3321, 2017. ,
Use of Nonradioactive Detection Method for North- and South-Western Blot, Methods in Molecular Biology, vol.1314, pp.63-71, 2015. ,
Identities and Phylogenetic Comparisons of Posttranscriptional Modifications in 16 S Ribosomal RNA fromHaloferax volcanii, Journal of Biological Chemistry, vol.275, issue.32, pp.24484-24489, 2000. ,
Sequence of human protamine 2 cDNA, Nucleic Acids Research, vol.16, issue.15, pp.7733-7733, 1988. ,
RNomics and Modomics in the halophilic archaea Haloferax volcanii: identification of RNA modification genes, BMC Genomics, vol.9, issue.1, p.470, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00354522
Structure of the Yeast tRNA m7G Methylation Complex, Structure, vol.16, issue.1, pp.52-61, 2008. ,
Two-subunit enzymes involved in eukaryotic post-transcriptional tRNA modification, RNA Biology, vol.11, issue.12, pp.1608-1618, 2014. ,
Structural insights into the molecular mechanism of the m(6)A writer complex. eLife, vol.5, p.18434, 2016. ,
Structural basis of N6-adenosine methylation by the METTL3?METTL14 complex, Nature, vol.534, issue.7608, pp.575-578, 2016. ,
Trm112, a Protein Activator of Methyltransferases Modifying Actors of the Eukaryotic Translational Apparatus, Biomolecules, vol.7, issue.4, p.7, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01948152
Evolutionary insights into Trm112-methyltransferase holoenzymes involved in translation between archaea and eukaryotes, Nucleic Acids Research, vol.46, issue.16, pp.8483-8499, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01910142
The Zinc Finger Protein Ynr046w Is Plurifunctional and a Component of the eRF1 Methyltransferase in Yeast, Journal of Biological Chemistry, vol.281, issue.47, pp.36140-36148, 2006. ,
Trm112p Is a 15-kDa Zinc Finger Protein Essential for the Activity of Two tRNA and One Protein Methyltransferases in Yeast, Journal of Biological Chemistry, vol.285, issue.24, pp.18505-18515, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00509840
Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding, Molecular and Cellular Biology, vol.30, issue.7, pp.1814-1827, 2010. ,
Trm112 Is Required for Bud23-Mediated Methylation of the 18S rRNA at Position G1575, Molecular and Cellular Biology, vol.32, issue.12, pp.2254-2267, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00709211
The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis, Molecular Biology of the Cell, vol.26, issue.11, pp.2080-2095, 2015. ,
Insights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure, Nucleic Acids Research, vol.43, issue.22, pp.10989-11002, 2015. ,
Activation mode of the eukaryotic m2G10tRNA methyltransferase Trm11 by its partner protein Trm112, Nucleic Acids Research, vol.45, p.gkw1271, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01953006
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases, Molecular Cell, vol.63, issue.2, pp.306-317, 2016. ,
Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor, Molecular Cell, vol.71, issue.6, pp.1001-1011.e4, 2018. ,
Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development, Molecular Cell, vol.71, issue.6, pp.986-1000.e11, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02976314
Structural insights into the RNA methyltransferase domain of METTL16, Scientific Reports, vol.8, issue.1, p.5311, 2018. ,
Cap-specific terminalN6-methylation of RNA by an RNA polymerase II?associated methyltransferase, Science, vol.363, issue.6423, p.eaav0080, 2018. ,
Gene expression regulation mediated through reversible m6A RNA methylation, Nature Reviews Genetics, vol.15, issue.5, pp.293-306, 2014. ,
The dynamic epitranscriptome: N6-methyladenosine and gene expression control, Nature Reviews Molecular Cell Biology, vol.15, issue.5, pp.313-326, 2014. ,
N6-methyladenosine?encoded epitranscriptomics, Nature Structural & Molecular Biology, vol.23, issue.2, pp.98-102, 2016. ,
The U6 snRNA m 6 A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention, Cell, vol.169, issue.5, pp.824-835.e14, 2017. ,
Human METTL16 is a N 6 ?methyladenosine (m 6 A) methyltransferase that targets pre?mRNAs and various non?coding RNAs, EMBO reports, vol.18, issue.11, pp.2004-2014, 2017. ,
Structure of the N6-adenine DNA methyltransferase M.TaqI in complex with DNA and a cofactor analog, Nat. Struct. Biol, vol.8, pp.121-125, 2001. ,
Visualizing late states of human 40S ribosomal subunit maturation, Nature, vol.558, issue.7709, pp.249-253, 2018. ,
The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution, Nature, vol.551, issue.7679, pp.251-255, 2017. ,
Acetylation of Cytidine in mRNA Promotes Translation Efficiency, Cell, vol.175, issue.7, pp.1872-1886.e24, 2018. ,
FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing, Nature, vol.565, pp.500-504, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-01981983
AlkAniline?Seq: Profiling of m 7 G and m 3 C RNA Modifications at Single Nucleotide Resolution, Angewandte Chemie International Edition, vol.57, issue.51, pp.16785-16790, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01928435
Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival, Molecular and Cellular Biology, vol.30, issue.10, pp.2449-2459, 2010. ,
The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by Interaction with TRMT112 via Ubiquitin-Proteasome Pathway, PLOS ONE, vol.10, issue.7, p.e0133841, 2015. ,
Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes, Cell, vol.167, issue.5, pp.1229-1240.e15, 2016. ,
MetaPlotR: a Perl/R pipeline for plotting metagenes of nucleotide modifications and other transcriptomic sites, Bioinformatics, vol.33, pp.1563-1564, 2017. ,