, the Fonds Jean Brachet, and the International Brachet Stiftung. Research in the laboratory of M.G. is supported by the Agence Nationale pour la Recherche
Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells, Proceedings of the National Academy of Sciences of the United States of America, vol.71, pp.3971-3975, 1974. ,
Existence of methylated messenger RNA in mouse L cells, Cell, vol.1, 1974. ,
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq, Nature, vol.485, pp.201-206, 2012. ,
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons, Cell, vol.149, pp.1635-1646, 2012. ,
Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers, Molecular cell, vol.74, pp.640-650, 2019. ,
Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase, Journal of molecular evolution, vol.55, pp.431-444, 2002. ,
Structural insights into the molecular mechanism of the m(6)A writer complex, vol.5, 2016. ,
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases, Molecular cell, vol.63, pp.306-317, 2016. ,
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex, Nature, vol.534, pp.575-578, 2016. ,
VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation, Cell discovery, vol.4, p.10, 2018. ,
m6A RNA methylation promotes XIST-mediated transcriptional repression, Nature, vol.537, pp.369-373, 2016. ,
Xio is a component of the Drosophila sex determination pathway and RNA N(6)-methyladenosine methyltransferase complex, Proceedings of the National Academy of Sciences of the United States of America, vol.115, pp.3674-3679, 2018. ,
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d, Genes & development, vol.32, pp.415-429, 2018. ,
Zc3h13 Regulates Nuclear RNA m(6)A Methylation and Mouse Embryonic Stem Cell Self-Renewal, Molecular cell, vol.69, p.1026, 2018. ,
Identification of factors required for m(6) A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI, The New phytologist, vol.215, pp.157-172, 2017. ,
The m(6)A Writer: Rise of a Machine for Growing Tasks, Biochemistry, vol.58, pp.363-378, 2019. ,
A fly view on the roles and mechanisms of the m6A mRNA modification and its players, RNA biology, 2017. ,
Mechanistic insights into m(6)A RNA enzymes, Biochimica et biophysica acta. Gene regulatory mechanisms, 2018. ,
, The U6 snRNA m, 2017.
, Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention, vol.169, pp.824-835
S-Adenosylmethionine Synthesis Is Regulated by Selective N(6)-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1, Cell reports, vol.21, pp.3354-3363, 2017. ,
Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs, EMBO reports, vol.18, pp.2004-2014, 2017. ,
, , 2018.
, Structured RNA by the m(6)A Writer METTL16 Is Essential for Mouse Embryonic Development, Molecular cell, vol.71, p.1011
Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function, RNA Biology, vol.14, issue.9, pp.1138-1152, 2016. ,
?View From A Bridge?: A New Perspective on Eukaryotic rRNA Base Modification, Trends in Biochemical Sciences, vol.40, issue.10, pp.560-575, 2015. ,
The 3D rRNA modification maps database: with interactive tools for ribosome analysis, Nucleic acids research, vol.36, pp.178-183, 2008. ,
N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation, Nature Chemical Biology, vol.15, issue.1, pp.88-94, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-02409786
Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis?, Molecular and cellular biology, vol.18, pp.2360-2370, 1998. ,
Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis, Molecular biology of the cell, vol.12, pp.3644-3657, 2001. ,
(Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis, Current genetics, vol.40, pp.326-338, 2002. ,
Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan, Nature communications, vol.6, p.6158, 2015. ,
Trm112, a Protein Activator of Methyltransferases Modifying Actors of the Eukaryotic Translational Apparatus, Biomolecules, vol.7, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01948152
Ribonucleoside analysis by reversed-phase high performance liquid chromatography, Journal, pp.3-71, 1990. ,
The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112, Nucleic acids research, vol.47, pp.7719-7733, 2019. ,
URL : https://hal.archives-ouvertes.fr/hal-02333696
Open source tracking and analysis of adult Drosophila locomotion in Buridan's paradigm with and without visual targets, PloS one, vol.7, p.42247, 2012. ,
The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis, Molecular biology of the cell, vol.26, pp.2080-2095, 2015. ,
) m6A modulates neuronal functions and sex determination in Drosophila, Nature, vol.540, pp.242-247, 2016. ,
Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation, Nature structural & molecular biology, vol.23, pp.116-124, 2016. ,
Automated selection of homologs to track the evolutionary history of proteins, BMC bioinformatics, vol.19, p.431, 2018. ,
MUSCLE: multiple sequence alignment with high accuracy and high throughput, Nucleic acids research, vol.32, pp.1792-1797, 2004. ,
Clustal W and Clustal X version 2.0, Bioinformatics, vol.23, pp.2947-2948, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00206210
High-resolution comparative modeling with RosettaCM, Structure, vol.21, pp.1735-1742, 2013. ,
No-bridge of Drosophila melanogaster: portrait of a structural brain mutant of the central complex, Journal of neurogenetics, vol.8, pp.125-155, 1992. ,