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Journal articles
A novel minimal motif for left-handed G-quadruplex formation
Abstract : A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.
https://hal-polytechnique.archives-ouvertes.fr/hal-03188419
Contributor : Aurélien Arnoux Connect in order to contact the contributor
Submitted on : Friday, April 2, 2021 - 1:29:55 PM
Last modification on : Friday, April 1, 2022 - 3:45:33 AM
Long-term archiving on: : Saturday, July 3, 2021 - 6:29:21 PM
Contributor : Aurélien Arnoux Connect in order to contact the contributor
Submitted on : Friday, April 2, 2021 - 1:29:55 PM
Last modification on : Friday, April 1, 2022 - 3:45:33 AM
Long-term archiving on: : Saturday, July 3, 2021 - 6:29:21 PM
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