 |
École polytechnique Open archive |  |
 |
Journal articles
A novel minimal motif for left-handed G-quadruplex formation
Abstract : A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.
https://hal-polytechnique.archives-ouvertes.fr/hal-03188419
Contributor : Aurélien Arnoux <>
Submitted on : Friday, April 2, 2021 - 1:29:55 PM
Last modification on : Saturday, April 3, 2021 - 3:28:12 AM
Long-term archiving on: : Saturday, July 3, 2021 - 6:29:21 PM
Contributor : Aurélien Arnoux <>
Submitted on : Friday, April 2, 2021 - 1:29:55 PM
Last modification on : Saturday, April 3, 2021 - 3:28:12 AM
Long-term archiving on: : Saturday, July 3, 2021 - 6:29:21 PM
File
Das-Accepted version.pdf
Files produced by the author(s)