A novel minimal motif for left-handed G-quadruplex formation - École polytechnique Access content directly
Journal Articles Chemical Communications Year : 2021

A novel minimal motif for left-handed G-quadruplex formation

Abstract

A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.
Fichier principal
Vignette du fichier
Das-Accepted version.pdf (511.98 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03188419 , version 1 (02-04-2021)

Identifiers

Cite

Poulomi Das, Fernaldo Richtia Winnerdy, Arijit Maity, Yves Mechulam, Anh Tuân Phan. A novel minimal motif for left-handed G-quadruplex formation. Chemical Communications, 2021, 57 (20), pp.2527-2530. ⟨10.1039/d0cc08146a⟩. ⟨hal-03188419⟩
55 View
70 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More