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Journal Articles Chemical Communications Year : 2021

A novel minimal motif for left-handed G-quadruplex formation

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Abstract

A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.
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hal-03188419 , version 1 (02-04-2021)

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Poulomi Das, Fernaldo Richtia Winnerdy, Arijit Maity, Yves Mechulam, Anh Tuân Phan. A novel minimal motif for left-handed G-quadruplex formation. Chemical Communications, 2021, 57 (20), pp.2527-2530. ⟨10.1039/d0cc08146a⟩. ⟨hal-03188419⟩
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