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Bulges in left-handed G-quadruplexes

Poulomi Das 1 Khac Huy Ngo 1 Fernaldo richtia Winnerdy 1 Arijit Maity 1 Blaž Bakalar 1 Yves Mechulam 2 Emmanuelle Schmitt 2 Anh Tuân Phan 1
1 Nanyang Technological University, School of Physical and Mathematical Sciences, Division of Chemistry and Biological Chemistry
2 BIOC - Laboratoire de Biologie Structurale de la Cellule
Abstract : G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.
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https://hal-polytechnique.archives-ouvertes.fr/hal-03188426
Contributor : Aurélien Arnoux <>
Submitted on : Friday, April 2, 2021 - 8:51:03 AM
Last modification on : Saturday, April 3, 2021 - 3:28:12 AM

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Poulomi Das, Khac Huy Ngo, Fernaldo richtia Winnerdy, Arijit Maity, Blaž Bakalar, et al.. Bulges in left-handed G-quadruplexes. Nucleic Acids Research, Oxford University Press, 2021, 49 (3), pp.1724-1736. ⟨10.1093/nar/gkaa1259⟩. ⟨hal-03188426⟩

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