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Bulges in left-handed G-quadruplexes

Abstract : G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.
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https://hal-polytechnique.archives-ouvertes.fr/hal-03188426
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Submitted on : Wednesday, October 6, 2021 - 1:59:32 PM
Last modification on : Friday, April 1, 2022 - 3:47:54 AM
Long-term archiving on: : Friday, January 7, 2022 - 6:57:38 PM

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Poulomi Das, Khac Huy Ngo, Fernaldo richtia Winnerdy, Arijit Maity, Blaž Bakalar, et al.. Bulges in left-handed G-quadruplexes. Nucleic Acids Research, Oxford University Press, 2021, 49 (3), pp.1724-1736. ⟨10.1093/nar/gkaa1259⟩. ⟨hal-03188426⟩

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