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Abstract : G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.
https://hal-polytechnique.archives-ouvertes.fr/hal-03188426 Contributor : Aurélien ArnouxConnect in order to contact the contributor Submitted on : Wednesday, October 6, 2021 - 1:59:32 PM Last modification on : Friday, April 1, 2022 - 3:47:54 AM Long-term archiving on: : Friday, January 7, 2022 - 6:57:38 PM