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Journal articles
Evolutionary mechanisms of circadian clocks
Abstract : An intriguing question in biology is to know how circadian molecular networks could have evolved their particular topologies to adjust to a daily period. We analyze the mechanism of the evolution of such networks by using a computational design strategy that allows for the generation of synthetic networks with a targeted 24 hours oscillation. We have performed a systematic analysis of all possible two-gene network topologies based on a core activator-repressor frequently found in circadian mechanisms. We have considered transcriptional and post-translational regulations to implement this core. We have applied our analysis to both, eukaryotic and prokaryotic circadian machinery. Finally, we conjecture a possible mechanism for the evolution of circadian clocks. © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2007.
https://hal-polytechnique.archives-ouvertes.fr/hal-00767094
Contributor : Denis Roura <>
Submitted on : Friday, January 4, 2013 - 1:15:18 PM
Last modification on : Wednesday, July 29, 2020 - 4:10:05 PM
Contributor : Denis Roura <>
Submitted on : Friday, January 4, 2013 - 1:15:18 PM
Last modification on : Wednesday, July 29, 2020 - 4:10:05 PM
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