A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process

Laurent Petit (1) , I. Botez (2) , A. Tizot (2) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique
2 Institut de Recherches Servier (IdRS)

Variously substituted novel dihydropyridoazepinones have been prepared by an intermolecular radical addition followed by a radical cyclisation on a pyridine ring. The latter process involved the use of a combination of two different peroxides, an experimental contrivance resulting from a careful product analysis and a better understanding of the cyclisation step. © 2012 Elsevier Ltd. All rights reserved.

Domains: Organic chemistry

Laurent Petit, I. Botez, A. Tizot, Samir Z. Zard. A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process. Tetrahedron Letters, 2012, 53 (26), pp.3220-3224. ⟨10.1016/j.tetlet.2012.04.020⟩. ⟨hal-00949980⟩