A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process

Laurent Petit; I. Botez; A. Tizot; Samir Zard

A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process

Laurent Petit ¹ I. Botez ² A. Tizot ² Samir Zard ^{1, *}

* Corresponding author

1 DCSO - Laboratoire de synthèse organique

Abstract : Variously substituted novel dihydropyridoazepinones have been prepared by an intermolecular radical addition followed by a radical cyclisation on a pyridine ring. The latter process involved the use of a combination of two different peroxides, an experimental contrivance resulting from a careful product analysis and a better understanding of the cyclisation step. © 2012 Elsevier Ltd. All rights reserved.

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

Complete list of metadatas

Cited literature [3 references] Display Hide Download

https://hal-polytechnique.archives-ouvertes.fr/hal-00949980
Contributor : Denis Roura <>
Submitted on : Monday, April 14, 2014 - 4:40:10 PM
Last modification on : Thursday, May 2, 2019 - 2:40:05 PM
Long-term archiving on : Sunday, April 9, 2017 - 2:25:00 PM

afra201201Z.pdf

Files produced by the author(s)

A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process

File

Identifiers

Collections

Citation

Export

Metrics

904

266

Contact

A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process

File

Identifiers

Collections

Citation

Export

Share

Metrics

904

266

Contact