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Multicomponent synthesis of fused benzimidazolopiperazines

Laurent El Kaim 1 Laurence Grimaud 1 Srinivas Reddy Purumandla 1
1 DCSO - Laboratoire de synthèse organique
Abstract : We present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi-Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cyclization, an intramolecular reductive cyclization, and an oxidation. © 2011 American Chemical Society.
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https://hal-polytechnique.archives-ouvertes.fr/hal-00951229
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Submitted on : Wednesday, February 26, 2014 - 9:21:11 PM
Last modification on : Thursday, March 5, 2020 - 6:25:21 PM

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Laurent El Kaim, Laurence Grimaud, Srinivas Reddy Purumandla. Multicomponent synthesis of fused benzimidazolopiperazines. Journal of Organic Chemistry, American Chemical Society, 2011, 76 (11), pp.4728-4733. ⟨10.1021/jo200397m⟩. ⟨hal-00951229⟩

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