Multicomponent synthesis of fused benzimidazolopiperazines

Abstract : We present a novel protocol for the efficient synthesis of fused benzimidazolo piperazines starting from a four-component Ugi-Smiles reaction and a subsequent three-step cascade involving an acid-catalyzed cyclization, an intramolecular reductive cyclization, and an oxidation. © 2011 American Chemical Society.
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Laurent El Kaim, Laurence Grimaud, Srinivas Reddy Purumandla. Multicomponent synthesis of fused benzimidazolopiperazines. Journal of Organic Chemistry, American Chemical Society, 2011, 76 (11), pp.4728-4733. ⟨10.1021/jo200397m⟩. ⟨hal-00951229⟩

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