Application of an amidyl radical cascade to the total synthesis of (±)-fortucine leading to the structural revision of kirkine

Abstract : A radical cascade initiated by a nitrogen-centred (amidyl) radical was developed, allowing the rapid construction of galanthan frameworks. It was applied to a concise, stereo/regio-selective and tin-free total synthesis of the natural product (±)-fortucine. This in turn resulted in the correction of the structure of kirkine. © 2009 Elsevier Ltd. All rights reserved.
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Aurélien Biechy, Shuji Hachisu, Béatrice Quiclet-Sire, Louis Ricard, Samir Zard. Application of an amidyl radical cascade to the total synthesis of (±)-fortucine leading to the structural revision of kirkine. Tetrahedron, Elsevier, 2009, 65 (33), pp.6730-6738. ⟨10.1016/j.tet.2009.04.027⟩. ⟨hal-00951265⟩

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