Application of an amidyl radical cascade to the total synthesis of (±)-fortucine leading to the structural revision of kirkine

Aurélien Biechy; Shuji Hachisu; Béatrice Quiclet-Sire; Louis Ricard; Samir Zard

Application of an amidyl radical cascade to the total synthesis of (±)-fortucine leading to the structural revision of kirkine

Aurélien Biechy ¹ Shuji Hachisu ¹ Béatrice Quiclet-Sire ¹ Louis Ricard ² Samir Zard ^{1, *}

* Corresponding author

1 DCSO - Laboratoire de synthèse organique

2 DCPH - Laboratoire Hétéroéléments et Coordination

Abstract : A radical cascade initiated by a nitrogen-centred (amidyl) radical was developed, allowing the rapid construction of galanthan frameworks. It was applied to a concise, stereo/regio-selective and tin-free total synthesis of the natural product (±)-fortucine. This in turn resulted in the correction of the structure of kirkine. © 2009 Elsevier Ltd. All rights reserved.

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Application of an amidyl radical cascade to the total synthesis of (±)-fortucine leading to the structural revision of kirkine

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Application of an amidyl radical cascade to the total synthesis of (±)-fortucine leading to the structural revision of kirkine

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