A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan

Alejandro Cordero-Vargas; Béatrice Quiclet-Sire; Samir Zard

doi:10.1016/j.bmc.2006.05.070

Journal articles

A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan

Alejandro Cordero-Vargas ¹ Béatrice Quiclet-Sire ¹ Samir Zard ^{1, *}

* Corresponding author

1 DCSO - Laboratoire de synthèse organique

Abstract : A practical preparation of benzazepine derivatives using a series of radical and ionic reactions is reported. This approach was applied to the synthesis of tolvaptan, a very promising vasopressin V2 receptor antagonist currently in clinical trials. © 2006 Elsevier Ltd. All rights reserved.

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Journal articles

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Chemical Sciences / Organic chemistry

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A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan

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A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan

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