Total synthesis of 10-norparvulenone and of O-methylasparvenone using a xanthate-mediated free radical addition - Cyclization sequence

Alejandro Cordero Vargas (1) , Béatrice Quiclet-Sire (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

(Matrix presented) A short synthesis of (±)-10-norparvulenone and (±)-O-methylasparvenone was developed starting from commercially available m-methoxyphenol, hinging on a xanthate-mediated addition - cyclization sequence for the construction of the a-tetralone subunit.

Domaines: Chimie organique

Alejandro Cordero Vargas, Béatrice Quiclet-Sire, Samir Z. Zard. Total synthesis of 10-norparvulenone and of O-methylasparvenone using a xanthate-mediated free radical addition - Cyclization sequence. Organic Letters, 2003, 5 (20), pp.3717-3719. ⟨10.1021/ol035394o⟩. ⟨hal-00954833⟩