A New, Simple, and Selective Palladium-Catalyzed Cleavage of Triethylsilyl Ethers

Delphine Rotulo-Sims (1) , Joëlle Prunet (1)

1 DCSO - Laboratoire de synthèse organique

(Equation Presented) A simple procedure for the cleavage of triethylsilyl (TES) ethers in the presence of 10 wt % Pd/C in methanol or 95% ethanol is reported. This method allows selective removal of alkyl TES ethers in the presence of aromatic TES ethers or tert-butyldimethylsilyl (TBS) protecting groups.

Domains: Chemical Sciences; Organic chemistry

Delphine Rotulo-Sims, Joëlle Prunet. A New, Simple, and Selective Palladium-Catalyzed Cleavage of Triethylsilyl Ethers. Organic Letters, 2002, 4 (26), pp.4701-4704. ⟨10.1021/ol0271382⟩. ⟨hal-00954849⟩