A new example of 1a-hydroxylation of drimanic terpenes through combined microbial and chemical processes

Gérard Aranda; L. Moreno; M. Cortés; T. Prangé; M. Maurs; R. Azerad

doi:10.1016/s0040-4020(01)00595-6

Journal articles

A new example of 1a-hydroxylation of drimanic terpenes through combined microbial and chemical processes

Gérard Aranda ¹ L. Moreno ² M. Cortés ² T. Prangé ³ M. Maurs ⁴ R. Azerad ⁴

1 DCSO - Laboratoire de synthèse organique

2 Facultad De Química

3 Chimie Structurale Biomoléculaire

4 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques

Abstract : Among various filamentous fungi, Aspergillus niger ATCC 9142 was the most efficient strain to convert confertifolin in high yield into its 3ß-hydroxy derivative, which was then chemically converted to 1a-hydroxy-, 1a,11a-dihydroxy- and 1a-acetoxy-11a-hydroxyconfertifolin, new compounds structurally related to bioactive natural products isolated from plants or marine sponges. © 2001 Elsevier Science Ltd.

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A new example of 1a-hydroxylation of drimanic terpenes through combined microbial and chemical processes

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A new example of 1a-hydroxylation of drimanic terpenes through combined microbial and chemical processes

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