The total synthesis of (+/-)-fortucine and a revision of the structure of kirkine. - Archive ouverte HAL Access content directly
Journal Articles Angewandte Chemie International Edition Year : 2008

The total synthesis of (+/-)-fortucine and a revision of the structure of kirkine.

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Abstract

The total synthesis of the natural product fortucine relies on a radical cascade process initiated by the generation of a nitrogen-centered (amidyl) radical (see picture). The procedure is concise, and tin-free, as well as stereo- and regioselective. This synthesis has enabled the correction of the structure of kirkine, and the strategy represents a general and rapid entry into the galanthan framework.

Dates and versions

hal-00969141 , version 1 (02-04-2014)

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Aurélien Biechy, Shuji Hachisu, Béatrice Quiclet-Sire, Louis Ricard, Samir Z. Zard. The total synthesis of (+/-)-fortucine and a revision of the structure of kirkine.. Angewandte Chemie International Edition, 2008, 47 (8), pp.1436-1438. ⟨10.1002/anie.200704996⟩. ⟨hal-00969141⟩
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