The total synthesis of (+/-)-fortucine and a revision of the structure of kirkine.

Abstract : The total synthesis of the natural product fortucine relies on a radical cascade process initiated by the generation of a nitrogen-centered (amidyl) radical (see picture). The procedure is concise, and tin-free, as well as stereo- and regioselective. This synthesis has enabled the correction of the structure of kirkine, and the strategy represents a general and rapid entry into the galanthan framework.
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Angewandte Chemie International Edition, Wiley-VCH Verlag, 2008, 47 (8), pp.1436-1438. 〈10.1002/anie.200704996〉
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https://hal-polytechnique.archives-ouvertes.fr/hal-00969141
Contributeur : Denis Roura <>
Soumis le : mercredi 2 avril 2014 - 10:31:05
Dernière modification le : jeudi 10 mai 2018 - 02:07:51

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Aurélien Biechy, Shuji Hachisu, Béatrice Quiclet-Sire, Louis Ricard, Samir Zard. The total synthesis of (+/-)-fortucine and a revision of the structure of kirkine.. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2008, 47 (8), pp.1436-1438. 〈10.1002/anie.200704996〉. 〈hal-00969141〉

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