 |
École polytechnique Open archive |  |
 |
Journal articles
The Nef Reaction of Isocyanides
Abstract : The interaction of isocyanides with acyl chlorides was first reported by Nef in 1892. The resulting α-keto imidoyl chlorides may be hydrolyzed to form α-keto amides. Relatively few data are available on this reaction and the chemistry of α-keto imidoyl chlorides has been largely underestimated until some recent uses in intra- and intermolecular couplings with a variety of nucleophiles. The present review brings a comprehensive presentation of the Nef reaction of isocyanides focusing on mechanism and regioselectivity issues.
https://hal-polytechnique.archives-ouvertes.fr/hal-01015399
Contributor : Denis Roura <>
Submitted on : Thursday, June 26, 2014 - 1:58:42 PM
Last modification on : Thursday, March 5, 2020 - 6:29:16 PM
Contributor : Denis Roura <>
Submitted on : Thursday, June 26, 2014 - 1:58:42 PM
Last modification on : Thursday, March 5, 2020 - 6:29:16 PM