Abstract : The interaction of isocyanides with acyl chlorides was first reported by Nef in 1892. The resulting α-keto imidoyl chlorides may be hydrolyzed to form α-keto amides. Relatively few data are available on this reaction and the chemistry of α-keto imidoyl chlorides has been largely underestimated until some recent uses in intra- and intermolecular couplings with a variety of nucleophiles. The present review brings a comprehensive presentation of the Nef reaction of isocyanides focusing on mechanism and regioselectivity issues.
Fabio La Spisa, Gian Cesare Tron, Laurent El Kaim. The Nef Reaction of Isocyanides. SYNTHESIS, Georg Thieme Verlag, 2014, 46 (7), pp.829-841. ⟨10.1055/s-0033-1338596⟩. ⟨hal-01015399⟩
