A Practical Source of Chlorodifluoromethyl Radicals. Convergent Routes to gem-Difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols.

Pierre Salomon; Samir Zard

doi:10.1021/ol501063a

Journal articles

A Practical Source of Chlorodifluoromethyl Radicals. Convergent Routes to gem-Difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols.

Pierre Salomon ^{1, *} Samir Zard ^{1, *}

* Corresponding author

1 DCSO - Laboratoire de synthèse organique

Abstract : The preparation of O-octadecyl-S-chlorodifluoromethyl xanthate from chlorodifluoroacetic acid and its use as a convenient source of chlordifluoromethyl radicals is described. This reagent may be used to access gem-difluoroalkenes and -dienes, as well as (2,2-difluoroethyl)indolines, -indoles, and -naphthols.

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

Complete list of metadata

https://hal-polytechnique.archives-ouvertes.fr/hal-01017932
Contributor : Denis Roura Connect in order to contact the contributor
Submitted on : Thursday, July 3, 2014 - 2:06:24 PM
Last modification on : Thursday, December 9, 2021 - 2:26:02 PM

A Practical Source of Chlorodifluoromethyl Radicals. Convergent Routes to gem-Difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols.

Identifiers

Collections

Citation

Export

Metrics

A Practical Source of Chlorodifluoromethyl Radicals. Convergent Routes to gem-Difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols.

Identifiers

Collections

Citation

Export

Share

Metrics