A Practical Source of Chlorodifluoromethyl Radicals. Convergent Routes to gem-Difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols.

Pierre Salomon; Samir Zard

doi:10.1021/ol501063a

A Practical Source of Chlorodifluoromethyl Radicals. Convergent Routes to gem-Difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols.

Pierre Salomon ^{1, *} Samir Zard ^{1, *}

* Auteur correspondant

1 DCSO - Laboratoire de synthèse organique

Abstract : The preparation of O-octadecyl-S-chlorodifluoromethyl xanthate from chlorodifluoroacetic acid and its use as a convenient source of chlordifluoromethyl radicals is described. This reagent may be used to access gem-difluoroalkenes and -dienes, as well as (2,2-difluoroethyl)indolines, -indoles, and -naphthols.

Type de document :

Article dans une revue

Organic Letters, American Chemical Society, 2014, 16 (11), pp.2926-2929. 〈10.1021/ol501063a〉

Domaine :

Chimie / Chimie organique

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https://hal-polytechnique.archives-ouvertes.fr/hal-01017932
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Soumis le : jeudi 3 juillet 2014 - 14:06:24
Dernière modification le : jeudi 10 mai 2018 - 02:07:45

A Practical Source of Chlorodifluoromethyl Radicals. Convergent Routes to gem-Difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols.

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A Practical Source of Chlorodifluoromethyl Radicals. Convergent Routes to gem-Difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols.

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