A Practical Source of Chlorodifluoromethyl Radicals. Convergent Routes to gem-Difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols.

Pierre Salomon (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

The preparation of O-octadecyl-S-chlorodifluoromethyl xanthate from chlorodifluoroacetic acid and its use as a convenient source of chlordifluoromethyl radicals is described. This reagent may be used to access gem-difluoroalkenes and -dienes, as well as (2,2-difluoroethyl)indolines, -indoles, and -naphthols.

Domains: Chemical Sciences; Organic chemistry

Pierre Salomon, Samir Z. Zard. A Practical Source of Chlorodifluoromethyl Radicals. Convergent Routes to gem-Difluoroalkenes and -dienes and (2,2-Difluoroethyl)-indoles, -azaindoles, and -naphthols.. Organic Letters, 2014, 16 (11), pp.2926-2929. ⟨10.1021/ol501063a⟩. ⟨hal-01017932⟩