Investigating the Cell Membrane via Single Particle Tracking, Bayesian Inference and Hydrodynamic Force Application

Maximilian Richly; Silvan Türkcan; Cédric Bouzigues; Michel R. Popoff; Jean-Baptiste Masson; Jean-Marc Allain; Antigoni Alexandrou

doi:10.1016/j.bpj.2013.11.3504

Journal articles

Investigating the Cell Membrane via Single Particle Tracking, Bayesian Inference and Hydrodynamic Force Application

Maximilian Richly ^{1, *} Silvan Türkcan ¹ Cédric Bouzigues ¹ Michel R. Popoff ² Jean-Baptiste Masson ³ Jean-Marc Allain ⁴ Antigoni Alexandrou ¹

* Corresponding author

1 LOB - Laboratoire d'optique et biosciences

2 Bactéries anaérobies et Toxines

3 Physique des Systèmes biologiques

4 LMS - Laboratoire de mécanique des solides

Abstract : We investigate the potential felt by membrane receptors inside membrane microdomains via tracking of single receptors labelled with rare-earth doped luminescent nanoparticles and Bayesian inference analysis of the recorded trajectories. We demonstrated that the potential felt by peptidic toxin receptors confined in lipid rafts is well described by a second-order polynomial potential, possibly due to an inhomogeneous lipid and protein distribution [Türkcan et al., Biophys. J. 2012] In contrast, the potential experienced by transferrin receptors in cytoskeleton-delimited microdomains is localized at the border of the confinement domain.

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Investigating the Cell Membrane via Single Particle Tracking, Bayesian Inference and Hydrodynamic Force Application

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