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Journal Articles Biophysical Journal Year : 2014

Investigating the Cell Membrane via Single Particle Tracking, Bayesian Inference and Hydrodynamic Force Application

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Abstract

We investigate the potential felt by membrane receptors inside membrane microdomains via tracking of single receptors labelled with rare-earth doped luminescent nanoparticles and Bayesian inference analysis of the recorded trajectories. We demonstrated that the potential felt by peptidic toxin receptors confined in lipid rafts is well described by a second-order polynomial potential, possibly due to an inhomogeneous lipid and protein distribution [Türkcan et al., Biophys. J. 2012] In contrast, the potential experienced by transferrin receptors in cytoskeleton-delimited microdomains is localized at the border of the confinement domain.

Dates and versions

hal-01048723 , version 1 (25-07-2014)

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Maximilian Richly, Silvan Türkcan, Cédric Bouzigues, Michel R. Popoff, Jean-Baptiste Masson, et al.. Investigating the Cell Membrane via Single Particle Tracking, Bayesian Inference and Hydrodynamic Force Application. Biophysical Journal, 2014, 106 (2), p633a. ⟨10.1016/j.bpj.2013.11.3504⟩. ⟨hal-01048723⟩
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