Investigating the Cell Membrane via Single Particle Tracking, Bayesian Inference and Hydrodynamic Force Application

Maximilian Richly 1, * Silvan Türkcan 1 Cédric Bouzigues 1 Michel R. Popoff 2 Jean-Baptiste Masson 3 Jean-Marc Allain 4 Antigoni Alexandrou 1
* Corresponding author
1 LOB - Laboratoire d'optique et biosciences
2 Bactéries anaérobies et Toxines
3 Physique des Systèmes biologiques
4 LMS - Laboratoire de mécanique des solides
Abstract : We investigate the potential felt by membrane receptors inside membrane microdomains via tracking of single receptors labelled with rare-earth doped luminescent nanoparticles and Bayesian inference analysis of the recorded trajectories. We demonstrated that the potential felt by peptidic toxin receptors confined in lipid rafts is well described by a second-order polynomial potential, possibly due to an inhomogeneous lipid and protein distribution [Türkcan et al., Biophys. J. 2012] In contrast, the potential experienced by transferrin receptors in cytoskeleton-delimited microdomains is localized at the border of the confinement domain.
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Submitted on : Friday, July 25, 2014 - 11:30:08 AM
Last modification on : Wednesday, March 27, 2019 - 4:16:23 PM

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Maximilian Richly, Silvan Türkcan, Cédric Bouzigues, Michel R. Popoff, Jean-Baptiste Masson, et al.. Investigating the Cell Membrane via Single Particle Tracking, Bayesian Inference and Hydrodynamic Force Application. Biophysical Journal, Biophysical Society, 2014, 106 (2), p633a. ⟨10.1016/j.bpj.2013.11.3504⟩. ⟨hal-01048723⟩

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