Investigating the Cell Membrane via Single Particle Tracking, Bayesian Inference and Hydrodynamic Force Application

Abstract : We investigate the potential felt by membrane receptors inside membrane microdomains via tracking of single receptors labelled with rare-earth doped luminescent nanoparticles and Bayesian inference analysis of the recorded trajectories. We demonstrated that the potential felt by peptidic toxin receptors confined in lipid rafts is well described by a second-order polynomial potential, possibly due to an inhomogeneous lipid and protein distribution [Türkcan et al., Biophys. J. 2012] In contrast, the potential experienced by transferrin receptors in cytoskeleton-delimited microdomains is localized at the border of the confinement domain.
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Biophysical Journal, Biophysical Society, 2014, 106 (2), p633a. 〈10.1016/j.bpj.2013.11.3504〉
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https://hal-polytechnique.archives-ouvertes.fr/hal-01048723
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Soumis le : vendredi 25 juillet 2014 - 11:30:08
Dernière modification le : jeudi 11 janvier 2018 - 06:23:17

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Maximilian Richly, Silvan Türkcan, Cédric Bouzigues, Michel R. Popoff, Jean-Baptiste Masson, et al.. Investigating the Cell Membrane via Single Particle Tracking, Bayesian Inference and Hydrodynamic Force Application. Biophysical Journal, Biophysical Society, 2014, 106 (2), p633a. 〈10.1016/j.bpj.2013.11.3504〉. 〈hal-01048723〉

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