Access to New Endoperoxide Derivatives by Electrochemical Oxidation of Substituted 3-Azabicyclo[4.1.0]hept-4-enes

Frédérick Nuter; Abdou Khadre Djily Dimé; Cheng Chen; Lotfi Bounaadja; Elisabeth Mouray; Isabelle Florent; Yvan Six; Olivier Buriez; Angela Marinetti; Arnaud Voituriez

Access to New Endoperoxide Derivatives by Electrochemical Oxidation of Substituted 3-Azabicyclo[4.1.0]hept-4-enes

Frédérick Nuter ¹ Abdou Khadre Djily Dimé ² Cheng Chen ³ Lotfi Bounaadja ⁴ Elisabeth Mouray ⁴ Isabelle Florent ⁴ Yvan Six ³ Olivier Buriez ² Angela Marinetti ¹ Arnaud Voituriez ¹

1 ICSN - Institut de Chimie des Substances Naturelles

2 PASTEUR - Processus d'Activation Sélective par Transfert d'Energie Uni-électronique ou Radiatif (UMR 8640)

3 DCSO - Laboratoire de synthèse organique

4 MCAM - Molécules de Communication et Adaptation des Micro-Organismes

Abstract : A series of substituted 3-azabicyclo[4.1.0]hept-4-ene derivatives were prepared and analysed by cyclic voltammetry. Preparative aerobic electrochemical oxidation reactions were then carried out. Three original endoperoxides were isolated, characterised and subjected to antimalarial and cytotoxicity activity assays.

Keywords : anti-plasmodial activity catalysis cycloisomerization electrochemistry endoperoxides

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

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https://hal-polytechnique.archives-ouvertes.fr/hal-01178411
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Submitted on : Monday, July 20, 2015 - 8:13:25 AM
Last modification on : Friday, May 24, 2019 - 5:24:29 PM

Access to New Endoperoxide Derivatives by Electrochemical Oxidation of Substituted 3-Azabicyclo[4.1.0]hept-4-enes

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Access to New Endoperoxide Derivatives by Electrochemical Oxidation of Substituted 3-Azabicyclo[4.1.0]hept-4-enes

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