PSSweb: protein structural statistics web server

Thomas Gaillard (1) , Roland H. Stote (2) , Annick Dejaegere (2)

1 BIOC - Laboratoire de Biochimie de l'Ecole polytechnique
2 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire

With the increasing number of protein structures available, there is a need for tools capable of automating the comparison of ensembles of structures, a common requirement in structural biology and bioinformatics. PSSweb is a web server for protein structural statistics. It takes as input an ensemble of PDB files of protein structures, performs a multiple sequence alignment and computes structural statistics for each position of the alignment. Different optional functionalities are proposed: structure superposition, Cartesian coordinate statistics, dihedral angle calculation and statistics, and a cluster analysis based on dihedral angles. An interactive report is generated, containing a summary of the results, tables, figures and 3D visualization of superposed structures.

Domaines: Biochimie, Biologie Moléculaire

Thomas Gaillard, Roland H. Stote, Annick Dejaegere. PSSweb: protein structural statistics web server. Nucleic Acids Research, 2016, 44 (W1), pp.W401 - W405. ⟨10.1093/nar/gkw332⟩. ⟨hal-01445474⟩