The xanthate route to organofluorine derivatives. A brief account

Abstract : The present account summarises routes to organofluorine derivatives based on the chemistry of xanthates developed in the author's laboratory. It concerns mostly radical pathways, but a few ionic transformations are also discussed. The degenerative reversible transfer of xanthates allows radical addition even to unactivated alkenes and tolerates numerous functional groups, in particular common polar groups such as ketones, esters, amides, carbamates, nitriles etc. Since the fluorine atoms can be placed on the alkene or the xanthate partner or on both, this opens a convergent approach to a vast array of otherwise inaccessible organofluorine structures that could be of interest to the pharmaceutical and agrochemical industries and to materials science.
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Article dans une revue
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2016, 14 (29), pp.6891-6912. 〈10.1039/c6ob01087c 〉
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Soumis le : samedi 4 février 2017 - 10:42:22
Dernière modification le : jeudi 11 janvier 2018 - 06:18:30

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Samir Z Zard. The xanthate route to organofluorine derivatives. A brief account . Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2016, 14 (29), pp.6891-6912. 〈10.1039/c6ob01087c 〉. 〈hal-01456157〉

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