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Inexpensive Radical Methylation and Related Alkylations of Heteroarenes

Abstract : A simple method for the introduction of a methyl and higher aliphatic group to various heteroarenes using very inexpensive reagents is described. It is based on the radical addition of a carboxylic xanthate followed by decarboxylation. Depending on the heteroarene structure, the decarboxylation can be spontaneous or induced by heating in N,N-dimethylacetamide or N-methyl pyrrolidone in a microwave oven.
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Qi Huang, Samir Z. Zard. Inexpensive Radical Methylation and Related Alkylations of Heteroarenes. Organic Letters, American Chemical Society, 2018, 20 (5), pp.1413-1416. ⟨10.1021/acs.orglett.8b00190⟩. ⟨hal-02091714⟩



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