Mannich reaction of trifluoroacetaldehyde hydrazones

Shuanglong Jia; Laurent El Kaim

Mannich reaction of trifluoroacetaldehyde hydrazones: a useful entry to trifluoromethyl substituted heterocycles

Shuanglong Jia ^{1, 2} Laurent El Kaim ^{2, 1, *}

* Corresponding author

1 DCSO - Laboratoire de synthèse organique

2 ENSTA Paris - École Nationale Supérieure de Techniques Avancées

Abstract : NH-aryl hydrazones derived from trifluoroacetaldehyde hemiacetal may be involved in efficient Mannich type reactions with formaldehydes and aromatic aldehydes. The resulting hydrazones are useful building blocks for the preparation of trifluoromethyl substituted heterocycles as shown by a straightforward preparation of 1,2-diazine derivatives under heating with β-ketoesters.

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

Complete list of metadatas

https://hal-polytechnique.archives-ouvertes.fr/hal-02095052
Contributor : Aurélien Arnoux <>
Submitted on : Wednesday, April 10, 2019 - 10:53:41 AM
Last modification on : Wednesday, July 3, 2019 - 10:48:05 AM

Mannich reaction of trifluoroacetaldehyde hydrazones: a useful entry to trifluoromethyl substituted heterocycles

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Mannich reaction of trifluoroacetaldehyde hydrazones: a useful entry to trifluoromethyl substituted heterocycles

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