Nef-Perkow cascade towards imidazo phosphate derivatives

Somayeh Ghorbani (1, 2) , Ebrahim Soleimani (2) , Laurent El Kaim (3, 1)

1 DCSO - Laboratoire de synthèse organique
2 Razi University of Kermanshah
3 ENSTA Paris - École Nationale Supérieure de Techniques Avancées

A one-pot four-component synthesis of imidazo phosphates has been achieved using a Nef/Perkow sequence followed by addition of propargylamine to form an intermediate amidrazone. The latter is not isolated but directly cyclized to imidazo phosphate derivatives in the presence of silver carbonate.

Keywords: Vinyl phosphate; Hydroamination; Isocyanide; Nef; Perkow

Domains: Organic chemistry

Somayeh Ghorbani, Ebrahim Soleimani, Laurent El Kaim. Nef-Perkow cascade towards imidazo phosphate derivatives. Tetrahedron Letters, 2017, 58 (49), pp.4595-4597. ⟨10.1016/j.tetlet.2017.10.055⟩. ⟨hal-02096435⟩