Nef-Perkow cascade towards imidazo phosphate derivatives

Somayeh Ghorbani; Ebrahim Soleimani; Laurent El Kaim

doi:10.1016/j.tetlet.2017.10.055

Journal articles

Nef-Perkow cascade towards imidazo phosphate derivatives

Somayeh Ghorbani ^{1, 2} Ebrahim Soleimani ^{2, *} Laurent El Kaim ^{3, 1, *}

* Corresponding author

1 DCSO - Laboratoire de synthèse organique

2 Razi University of Kermanshah

3 ENSTA Paris - École Nationale Supérieure de Techniques Avancées

Abstract : A one-pot four-component synthesis of imidazo phosphates has been achieved using a Nef/Perkow sequence followed by addition of propargylamine to form an intermediate amidrazone. The latter is not isolated but directly cyclized to imidazo phosphate derivatives in the presence of silver carbonate.

Keywords : Vinyl phosphate Hydroamination Isocyanide Nef Perkow

Document type :

Journal articles

Domain :

Chemical Sciences / Organic chemistry

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https://hal-polytechnique.archives-ouvertes.fr/hal-02096435
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Submitted on : Thursday, April 11, 2019 - 12:41:32 PM
Last modification on : Wednesday, July 3, 2019 - 10:48:05 AM

Nef-Perkow cascade towards imidazo phosphate derivatives

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Nef-Perkow cascade towards imidazo phosphate derivatives

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