Synthesis and characterization of new neutral Mn(I) tricarbonyl complexes with 8‐hydroxyquinoline and imidazole ligands as CO releasing molecules

Marcel Annereau (1) , Franck Martial (1) , Jérémy Forté (2) , Geoffrey Gontard (2) , Sébastien Blanchard (3) , Héloïse Dossmann (4) , Michèle Salmain (1) , Vincent Corcé (1)

1 CHEMBIO - Chemical Biology
2 IPCM - Institut Parisien de Chimie Moléculaire
3 E-POM - Edifices PolyMétalliques
4 CSOB - Chimie Structurale Organique et Biologique

A series of manganese(I) tricarbonyl complexes formulated as [Mn(8-HQ)(CO)3Imd] (HQ = hydroxyquinoline and Imd = imidazole derivatives) was synthesized and fully characterized. These structures could be easily accessed from a common dimeric edifice formulated as [Mn2(8-HQ)2(CO)6]. The structure of this complex has been confirmed by X-ray diffraction studies. Its reaction with a range of imidazole derivatives (Imd) yielded the monomeric complexes [Mn(8-hydroxyquinoline)(CO)3Imd] with various functional groups as an anchoring point for a vector. Photoactivation of all these complexes by blue-light irradiation led to the liberation of 3 mol of CO per mol of complex as determined experimentally. Spectroscopic and computational methods were employed to explore the mechanism of CO release. Finally, a manganese complex including the more elaborate imidazole ligand N- and C-di-protected histidine was successfully synthesized, opening the way to its direct incorporation in peptides.

Domaines: Chimie de coordination

Marcel Annereau, Franck Martial, Jérémy Forté, Geoffrey Gontard, Sébastien Blanchard, et al.. Synthesis and characterization of new neutral Mn(I) tricarbonyl complexes with 8‐hydroxyquinoline and imidazole ligands as CO releasing molecules. Applied Organometallic Chemistry, 2023, 37 (8), pp.e7171. ⟨10.1002/aoc.7171⟩. ⟨hal-04153673⟩