Phosphite-mediated synthesis of benzimidazoles: A one-pot four-component approach from nitrophenols

Laurent El Kaim (1) , Laurence Grimaud (1) , Srinivas Reddy Purumandla (1)

1 DCSO - Laboratoire de synthèse organique

Benzimidazoles may be formed in high yield through the phosphite-triggered reductive cyclization of o-nitroaniline derivatives. This reaction was used for the one-pot synthesis of benzimidazoles from o-nitrophenols and isocyanides. The mechanism is discussed in relation with nitroso intermediates. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Laurent El Kaim, Laurence Grimaud, Srinivas Reddy Purumandla. Phosphite-mediated synthesis of benzimidazoles: A one-pot four-component approach from nitrophenols. European Journal of Organic Chemistry, 2011, - (31), pp.6177-6180. ⟨10.1002/ejoc.201100939⟩. ⟨hal-00951232⟩